Sentences with phrase «changing microenvironment»

Polysaccharide fraction of Agaricus brasiliensis avoids tumor - induced IL - 10 production and changes the microenvironment of subcutaneous Ehrlich adenocarcinoma.

A tumor can change its microenvironment, and the microenvironment can affect how a tumor grows and spreads.

Not exact matches

The starter culture changes the cheese microenvironment, affecting a variety of factors, including pH, redox potential, levels of organic acids such as lactate and acetate, and other nutrients.

The acceleration of the healing process occurs due to changes in the microenvironment in the wound, which change the behaviour of specific immune cells.

Changing the concentration of the enzyme's substrate molecule in the model produced an outcome that described how ATP synthase interacts with its microenvironment.

Changes in the ovarian microenvironment, such as reduced oxygen supply to the growing follicles are likely causes of ovarian aging, according to Patrizio.

Wistar scientists have previously shown that age - related changes in the tumor microenvironment — or the surrounding area where tumor cells crosstalk with normal and immune cells — can drive melanoma progression and therapy resistance.

The researchers analyzed the samples using immunohistochemistry and RNA sequencing to study the changes in the tumor immune microenvironment of patients who received and did not receive chemotherapy, and changes before and after chemotherapy.

Wherever they gather, mitochondria change the local chemical microenvironment: They cause a lower pH, and that small change, Van Blerkom believes, can affect the local activity of certain enzymes.

When they put stem cells into this viscoelastic microenvironment and tuned the rate at which the gel relaxed, they observed dramatic changes in the behavior and differentiation of the cells.

One reason that fast - relaxing microenvironments promote more osteogenesis and form bone is that cells inside these matrices can mechanically remodel the matrix and more easily change shape, said Ovijit Chaudhuri, former postdoctoral fellow in the Mooney lab and co-first author.

In the current study, the authors used single - cell RNA sequencing (RNA - Seq) to monitor how individual cells change when they are combined in a three - dimensional (3D) microenvironment.

In both cases, paclitaxel changed the tumor microenvironments in three ways, all more conducive to metastasis: The microenvironment had more of the immune cells that carry cancer cells into blood vessels, it developed blood vessels that were more permeable to cancer cells, and the tumor cells became more mobile, practically bounding into those molecular Lyfts.

«Our data suggest that early - stage HER2 - positive breast cancers treated with neoadjuvant combination docetaxel, carboplatin, and trastuzumab with or without pertuzumab demonstrate tumor immune microenvironment phenotype changes,» the authors concluded.

It is important to understand changes in this microenvironment, because it might have consequences for air - sea interactions that are relevant for our climate.»

Collectively, our results support the idea that a stem - like subpopulation in the tumor could expand selectively in response to changes in the microenvironment.

The team is also studying changes in the tumor microenvironment — the cells that support cancerous cells in a tumor — to see if there are changes and the environment is more or less «inhabitable» following treatment.

She is also interested in examining the changes in the tumor microenvironment and how they affect melanoma progression and therapy resistance.

The researchers found that loss of collagen VII not only affected the composition of the cellular microenvironment but also led to global changes in cell homeostasis on mRNA and on protein level.

Despite their fundamental importance in the regulation of cell physiology, the mechanisms that confer cell adaptability to changes in the microenvironment are poorly understood.

Melanoma incidence is increased in elderly patients, who also have a worse prognosis, and this could be due to a number of age - related factors, such as a lower immunity, but may also be due to changes in the aging microenvironment.

Since heterogeneity in the tumor microenvironment, such as the presence of a neighboring blood vessel, may drive genetic changes, he reasoned that it might also be reflected on the level of proteins.

The starter culture changes the cheese microenvironment, affecting a variety of factors, including pH, redox potential, levels of organic acids such as lactate and acetate, and other nutrients.

Often, hot spots may occur after a dog has been swimming in a lake or river, likely because this changes the temperature and humidity of the skin microenvironment.

After introducing the nanoparticles, they found changes in both specific characteristics of the microbial community and of the gut microenvironment.