The process transforms the adult cells into pluripotent stem cells, which seem to share the key
characteristics of embryonic stem cells but do not require the creation, use, or destruction of a human embryo.
The researchers took skin cells from the tails of sickle cell mice and inserted copies of four genes that made the cells take on
the characteristics of embryonic stem cells.
These cells reportedly possessed many of the same
characteristics of embryonic stem cells, without requiring the ethically problematic destruction of embryos.
Not exact matches
They also showed that the
cells have most
of the surface «markers» considered as identifiers
of embryonic stem cells and form «embryoid bodies» —
characteristic clumps
of cells formed by ESCs.
Future research should not only compare how
embryonic stem cells, iPS
cells and adult
stem cells differentiate, but focus on what effects the niche in which these
cells will reside, when transplanted, will have on their
characteristics, including tendencies to mutate into cancer
cells, notes
cell and
stem cell biologist Olga Genbacev at the University
of California, San Francisco, (U.C.S.F.) School
of Medicine.
The researchers discovered that this region is required to both turn Sox2 on, and for the
embryonic stem cells to maintain their
characteristic appearance and ability to differentiate into all the
cell types
of the adult organism.
In a statement put on the Web this morning, NIH reported that all 64 lines «show
characteristics of stem cell morphology» and have undergone several population doublings, and most
of them have demonstrated all the protein markers «known to be associated with human
embryonic stem cells.»
Researchers from the University
of California, Berkeley, have found a way to reprogram mouse
embryonic stem cells so that they exhibit developmental
characteristics resembling those
of fertilized eggs, or zygotes.
The scientists already knew how to encourage mouse
embryonic stem cells to express nestin, and they wondered if they could coax their nestin - positive
cells to take on more
characteristics of pancreas
cells.
The team injected about 2000 mouse
embryonic stem cells each into the brains
of 25 rats who had previously had their dopamine - producing neurons damaged, which causes a
characteristic tendency to move in circles.
Mouse
embryonic stem cells injected into rat brains express the AHD2 protein marker (yellow)
characteristic of cells lost in Parkinson's disease.
A team
of German scientists reported today that it has succeeded in turning
stem cells that become sperm in mice into
cells with many
of the
characteristics of embryonic stem (ES)
cells.
The
characteristic aggregation
of lipid - containing structures around the
embryonic nuclei clearly detected in C. elegans embryos by CARS microscopy are reminiscent
of lipid droplets recently reported to be a
characteristic feature
of cancer
stem cells in colorectal carcinomas (Tirinato et al., 2015).
NeuroStemcell is focused on the identification and systematic comparison
of progenitor
cell lines with the most favourable
characteristics for mesDA and striatal GABAergic neuronal differentiation, generated either directly from human
embryonic stem (ES) cells, from Neural Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
stem (ES)
cells, from Neural
Stem (NS) cells derived from ES cells or fetal brain, from induced Pluripotent Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (NS)
cells derived from ES
cells or fetal brain, from induced Pluripotent
Stem (iPS) cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing of the most prominent candidate cells in appropriate animals mod
Stem (iPS)
cells or from in vitro short - term expanded neural progenitors from ventral midbrain grown as neurospheres (VMN, Ventral Midbrain Neurospheres) 4, and perform rigorous and systematic testing
of the most prominent candidate
cells in appropriate animals models.
Yamanaka and Takahashi began their search by studying
embryonic stem cells in the hope
of identifying the genes that underlie essential
stem cell characteristics, such as pluripotency and proliferation, a
cell's ability to replicate itself.
While it is widely accepted that
embryonic stem cells (ESCs) have the ability to become any type
of cell, the molecular causes for this
characteristic are still under much investigation, although one suspected player is chromatin.
A human
embryonic stem cell is reined in — prevented from giving up its unique
characteristics of self - renewal and pluripotency — by the presence
of a protein modification that stifles any genes that would prematurely instruct the
cell to develop into heart or other specialized tissue.