Sentences with phrase «characterized by a progressive»
MIN - 102 has a unique mechanism of action for X-ALD, a genetic disease characterized by progressive neurologic deterioration with no available pharmacological treatment.
http://www.minoryx.com/
The CNS related effects lead to two main phenotypes: adrenomyeloneuropathy, (AMN) characterized by progressive motor dysfunction, and cerebral ALD (cALD), characterized by severe neuroinflammation leading to early death.
Minoryx harnesses its unique mechanism of action for potential use in X-ALD, a genetic disease characterized by progressive neurologic deterioration with no available pharmacological treatment.
It is the most common form of inherited ataxia, a condition characterized by a progressive loss of coordinated movement and balance.
Muscular dystrophies are a group of more than 30 genetic diseases characterized by progressive weakness and degeneration of the skeletal muscles that control movement.
About two million people in Europe suffer from chronic inflammatory bowel diseases, which are characterized by progressive tissue destruction and that often necessitate removal of sections of the intestine.
Late - onset Alzheimer's disease — the subset of the disorder occurring in people age 65 and over — affects more than 5 million Americans, and is characterized by progressive memory loss and dementia.
DCM is a disease characterized by progressive weakening and enlargement of the heart muscle, which can lead to heart failure and premature death.
It is characterized by progressive damage to the joint cartilage — the cushioning material at the end of long bones — and causes changes in the structures around the joint.
«I don't think that you want to intervene in a disease that is characterized by progressive immunosuppression with immunosuppression.»
ALS is characterized by degeneration of motor neurons, while FTD is characterized by progressive neuronal loss mostly in the frontal and / or temporal lobes of the brain.
Muscular dystrophy is a group of genetic diseases characterized by progressive muscle degeneration.
The most common form is Duchenne muscular dystrophy which is characterized by progressive muscle degeneration and ultimately death due to heart and / or respiratory failure.
We identified a family quartet with two children, both affected with a previously unreported disease, characterized by progressive muscular weakness and cardiomyopathy, with normal intelligence.
PD is characterized by the progressive degeneration of midbrain dopaminergic (mDA) neurons, and the accumulation of neuronal inclusions of aggregated α - synuclein [2].
The most common form affects infants and young children, and is characterized by progressive failure of central myelination, usually leading to death usually within the first decade.
Summary: Glaucoma is a leading cause of irreversible blindness worldwide and is characterized by progressive destruction of neural connections between retinal ganglion cells and the brain.
In a second study, published in the journal Stem Cells Translational Medicine, the team showed that in rodents they could use the same type of lung cell to successfully treat a model of IPF — a chronic, irreversible, and ultimately fatal disease characterized by a progressive decline in lung function.
Aging is characterized by progressive loss of physiological and cellular functions, but the molecular basis of this decline remains unclear.
Singer Linda Ronstadt has released a new book of memoirs and in it she reveals that she, like 60,000 Americans each year, was given a diagnosis of Parkinson's, a disease characterized by progressive degeneration of the brain.
Alzheimer's disease is characterized by progressive damage to nerve cells and their connections.
«Indeed, even physiological aging is characterized by a progressive decline of motor abilities and patho - anatomic features of neuronal degeneration in the brain, which in many ways are similar to key characteristics of PD (but which do not evoke clinically - relevant signs of PD).»
It is found in male Labrador retriever dogs and characterized by progressive skeletal muscle atrophy beginning shortly after birth, causing short strides and slow movement compared to littermates and eventually fatally impairing the dog's gait.
Botulism is characterized by progressive motor paralysis.
Not exact matches
Mary's ancestry, like Joseph's, was characterized by the predominance of strong but average individuals, relieved now and then by numerous outstanding personalities in the march of civilization and the progressive evolution of religion.
Some sectors, both conservative and progressive, have responded critically and defensively by characterizing Pentecostals as a dangerous foreign threat.
A growing segment of society, the «engaged progressives,» as the University of Virginia Family Cultures Study calls them, is characterized by its firm rejection of transcendent norms.
This mass media has always been characterized by a more progressive worldview, so left - leaning narratives are the only kinds of stories that we heard for generations.
Preeclampsia is defined by the website preeclampsia.org as «a rapidly progressive condition characterize by high blood pressure and the presence of protein in the urine.»
The Peoples Democratic Party, PDP, says the string of false alarms and outright lies that characterized Wednesday's press conference addressed by the All Progressives Congress, APC, has clearly justified its profiling as a party of «one week, one lie».
Cirrhosis is a consequence of chronic liver disease characterized by replacement of liver tissue by fibrotic scar tissue as well as regenerative nodules, leading to progressive loss of liver function.
The symptoms of Parkinson's — which is characterized by stiffness and can lead to a loss of motor and speech function — are triggered by the progressive death of neurons in a midbrain region called the substantia nigra that produce the neurotransmitter dopamine (implicated in the pleasure and reward systems as well as in the maintenance of proper movement control).
Mitochondrial diseases include Leigh syndrome, a progressive and fatal disorder characterized by lesions on the brain that may lead to heart, kidney, vision and breathing complications, and Alpers Disease, a neurologic illness that causes seizures, dementia, spasticity, blindness, liver dysfunction and cerebral degeneration.
It is a progressive, fatal disease characterized by scarring deep in the lung tissue that leads to respiratory or heart failure, pneumonia, and pulmonary embolism.
Osteoporosis, a progressive bone disease characterized by decreased bone mass and an increase in fractures, affects over 200 million people worldwide.
It is characterized by the wasting of skeletal muscles and caused by progressive degeneration of nerve cells in the spinal cord; the disease leads to increasing muscular weakness, atrophy and premature death due to respiratory problems.
In both diseases the pathology is slowly progressive and characterized by the preferential loss of one type of neuron, i.e., the mesencephalic dopamine (mesDA) neurons in PD and the GABAergic medium sized spiny neurons in HD.
Muscular dystrophies are diseases of the muscle characterized by muscle fiber degeneration and associated progressive muscle weakness.
A. Chronic pancreatitis is a progressive disease characterized by ongoing inflammation of the pancreas.
Corticobasal degeneration is a progressive neurological disorder characterized by nerve cell loss and atrophy (shrinkage) of various regions of the brain, including the cerebral cortex and the basal ganglia (which helps to start and control movements, as well as other functions).
About SMA SMA is a severe neuromuscular disease characterized by the loss of motor neurons leading to progressive muscle weakness and paralysis.
Parkinson's disease (PD) is a progressive neurodegenerative disorder that is characterized by the loss of dopamine neurons in the substantia nigra pars compacta, culminating in severe motor symptoms,
The progressive neurodegenerative disorder Huntington's disease (HD), which is caused by a polyglutamine repeat expansion within the huntingtin protein, is characterized by movement disorders, cognitive impairment and psychiatric symptoms.
The disease is characterized by an insidious onset, followed by progressive cognitive decline, psychiatric disturbances, and motor impairment.
Chronic obstructive pulmonary disease, or COPD, is a progressive respiratory disease characterized by shortness of breath and cough with sputum production.
FA is a hereditary DNA - repair disorder characterized by various congenital abnormalities, progressive bone marrow failure, and cancer predisposition.
Dementia is characterized by the gradual and progressive loss of memory, thought, and mental abilities.
Rheumatoid arthritis is a chronic, systemic autoimmune disease characterized by persistent pain and stiffness, along with progressive joint destruction, particularly in the hands and feet, leading to crippling deformities.
Fast Track Boxing training consist of HIT (High - Intensity Training) which is a form of progressive resistance exercise characterized by a high level of effort in a brief period of time.
It is characterized by persistent pain and stiffness, along with progressive joint destruction, particularly in the hands and feet, leading to crippling deformities.