His studies revealed that the blood and lymphatic vasculature, fibroblasts, immune cells and the extracellular matrix associated with tumors are abnormal, collectively creating a hostile tumor microenvironment
characterized by hypoxia, low pH and high interstitial fluid pressure.
Not exact matches
The irregular vasculature of solid tumors creates hypoxic regions, which are
characterized by cyclic periods of
hypoxia and reoxygenation.
91 Normal functioning of adipose tissue is often (but not exclusively) impaired in obesity 91 and can be
characterized by excessive hypertrophic adipocyte growth, elevated macrophage infiltration,
hypoxia and dysregulated lipid storage.92