Sentences with phrase «characterized cell models»

Not exact matches

A newly characterized group of pharmacological compounds block both the inflammation and nerve cell damage seen in mouse models of multiple sclerosis, according to a study conducted at the Icahn School of Medicine at Mount Sinai and published online this week in the journal Nature Neuroscience.

Now, a team of scientists at the Icahn School of Medicine at Mount Sinai have developed the Just EGFP Death - Inducing T - cell, or JEDI T - cells, which enable the visualization of T - cell antigens, allowing researchers to study T - cell interactions with different cell types, model disease states, and finally determine the functions of otherwise poorly characterized cell populations.

«Usually, when researchers want a mouse or other animal model to express fluorescent proteins in certain cells, they need to develop genetically modified animals that can take months to years to make and characterize,» says former graduate student and first author Ken Chan (PhD» 17).

He is also developing a robust and comprehensive panel of 3 - D cell culture models from patient - derived primary cells that can be used to characterize different disease phenotypes and investigate the chemo - response of cells to novel or known drugs.

The current work, she explains, uses antibodies that were generated and characterized at CNDR previously to see if they would reduce the pathology both in cell culture and in animal models.

The study used whole - exome sequencing to characterize genetic alterations that occur at the single nucleotide level for all genes in 25 cell lines commonly used as models of bladder cancer.

Second, we will characterize the effect of stretch on cells isolated from mouse glaucoma models.

The goal of this work is to characterize the role of dendrites in learning and memory processes so as to formulate a unifying theory regarding their contribution in memory formation across brain regions and abstraction levels.This will be achieved via the development of computational models that start at the single cell level and expand to the microcircuit and the network level, while varying in their degree of biophysical detail.

Such cells exhibit properties characteristic of functional human adult pancreatic insulin producing cells and provide protection in an animal model of diabetes characterized by loss of pancreatic insulin producing cells.

Working with Dr. Weiskopf, we established a model of human dengue disease using HLA transgenic mouse strains, and characterized human dengue - specific CD8 + and CD4 + T - cell responses in natural infection as well as following vaccination.

Next, we describe the biophysical tools that have been developed in recent years to characterize and model cancer cell mechanics.

In a second study, published in the journal Stem Cells Translational Medicine, the team showed that in rodents they could use the same type of lung cell to successfully treat a model of IPF — a chronic, irreversible, and ultimately fatal disease characterized by a progressive decline in lung function.

Here, Dr. Tam presents data characterizing the intracellular signaling pathway associated with the RANK — RANKL axis, as well as the effect in dendritic cells, antigen - specific T cells, cytokines, and chemokine profiles after in vivo treatment with blocking PD - L1 and T cell - depleting antibodies in a melanoma cancer model.