Sentences with phrase «characterized gene disruption»
Using global transposon mutagenesis, we isolated and characterized gene disruption mutants for 100 different nonessential protein - coding genes.
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Through temporary disruption of these interactions, the scientists were able to produce Drosophila epilines characterized by different levels of PcG - dependent gene repression or activation.
In addition to genomic sequencing, the BDGP is 1) producing gene disruptions using P element - mediated mutagenesis on a scale unprecedented in metazoans; 2) characterizing the sequence and expression of cDNAs; and 3) developing informatics tools that support the experimental process, identify features of DNA sequence, and allow us to present up - to - date information about the annotated sequence to the research community.