Sentences with phrase «checkpoint inhibition»
"Checkpoint inhibition" refers to a medical approach where the body's natural immune system is allowed to attack cancer cells more effectively. Normally, cancer cells have certain safety mechanisms called "checkpoints" that prevent the immune system from destroying them. In checkpoint inhibition, these safety mechanisms are blocked, enabling the immune system to recognize and attack the cancer cells effectively, stopping them from growing and spreading. Full definition
Ongoing research involves the evaluation of immune checkpoint inhibition in collaboration with the Ludwig / CRI CVC trials network and the pharmaceutical industry.
onjcancercentre.org
Owing to the unique capability of flow cytometry to measure events at a single - cell level, «Phospho Flow» allows for the identification of rare signaling events during co-stimulation and manipulation of checkpoint inhibition.
In this video, Yousef N. Zakharia, MD, of the Holden Comprehensive Cancer Center and division of hematology and medical oncology at the University of Iowa, discusses phase II results of a single - arm trial that tested checkpoint inhibition plus indoximod, an IDO - pathway inhibitor, in patients with advanced melanoma.
All patients were treatment - naive for checkpoint inhibition.
There was concern that stimulating the immune system while «cutting the brakes» with checkpoint inhibition could lead to increased incidence or severity of side effects, but that was not the case.
An accompanying study led by researchers at the University of Pennsylvania and co-authored by Dana - Farber scientists reports that these differences in circuitry remain largely unchanged by a type of cancer immunotherapy known as checkpoint inhibition, potentially closing off one avenue of improving this technique.
However, unfortunately, the vast majority of patients do not respond to checkpoint inhibition therapy and a minority of patients, who do respond to treatment, develop secondary resistance and experience relapse by mechanisms still inadequately understood.
«The ability to predict progression to stage IV disease is extremely important in light of recent findings that immune checkpoint inhibition improves OS in stage III melanoma,» the researchers wrote.
PD - L1 checkpoint inhibition and anti-CTLA-4 whole tumor cell vaccination counter adaptive immune resistance: A mouse neuroblastoma model that mimics human disease.
This video examines phase II results of a single - arm trial that tested checkpoint inhibition plus the IDO — pathway inhibitor indoximod in patients with melanoma.
The laboratory of Linda Bradley, Ph.D., professor at SBP, recently published a paper identifying PSGL - 1, a protein that limits T cell responses to viruses, as a new target for checkpoint inhibition, an approach akin to taking the «brakes» off the immune system.
Emerging evidence shows that alterations in multiple signaling pathways are involved in primary and / or secondary resistance to checkpoint inhibition.
In this review we discuss how selected cancer - cell autonomous cues may influence the outcome of cancer immunotherapy, particularly immune checkpoint inhibition.
In general, not all patients respond to checkpoint inhibition, suggesting the need for other approaches, such as that pursued with enfortumab vedotin.
«There are many patients that either initially respond to checkpoint inhibition and then progress, or never respond to this therapy to begin with,» said Mohammed Milhem, MBBS, of the University of Iowa in Iowa City, according to a press release.