Sentences with phrase «checkpoint molecules»
"Checkpoint molecules" refer to certain proteins found on immune cells that act as signals to either activate or inhibit the immune response in the body. They help the immune system maintain a balance in regulating the immune response to prevent it from becoming too weak or overly active. Full definition
«Although we found that chemotherapy activated the T cells, the levels of the protein PD - L1 [to which the immune checkpoint molecule PD - 1 binds to disable T cells and prevent them from recognizing and destroying the cancer cells] remained the same or increased.
sciencedaily.com
AMD3100, alone or in combination with VIC - 008, decreases expression of the immune checkpoint molecule PD - 1 on CD8 T cells, implying that the CXCR4 / CXCR12 pathway modulates PD - 1 expression.
Monitor the expression of B7 - H1 / PD - L1 and other checkpoint molecules with antibodies suitable for IHC, flow cytometry, and Western blot.
To overcome that problem, pharmaceutical companies have developed a number of different antibody proteins that block these overexpressed checkpoint molecules and enable the immune system to target tumors.
Vladimir Vigdorovich, Ph.D., a CRI postdoctoral fellow at Albert Einstein College of Medicine, studies B7x, which is an immune checkpoint molecule that can inhibit T cell function.
In this study, using a mouse transgenic approach, the scientists demonstrated that ILC2s express a checkpoint molecule, known as «PD - L1», that functions to control the expansion of allergy - inducing Th2 cells and the development of allergic pulmonary and gut tissue inflammation.
«There is a family of such checkpoint molecules like ICOS, but ICOS has a capability that is not shared with other checkpoint molecules.
In some cases, even when the checkpoint molecules are blocked that there are too few active T cells around to sound the immune alarm, says Jedd Wolchok, a cancer immunotherapy expert at the Memorial Sloan Kettering Cancer Center in New York City.
Tumor cells often over express these checkpoint molecules, putting the brakes on the immune system's search and destroy work.
The mismatch repair defective subset of CRC selectively up - regulates at least 5 checkpoint molecules that are targets of inhibitors currently being clinically tested.
Additionally, she is investigating the role of circulating tumor cells expressing these checkpoint molecules.