Sentences with phrase «checkpoint pathways»
"Checkpoint pathways" refer to the series of molecular signals or processes that regulate and monitor the progression of crucial events, such as cell division or DNA damage repair, in living organisms. These pathways ensure that each step is accurately completed before moving on to the next, to maintain the integrity and functionality of cells and organisms. Full definition
How much checkpoint inhibitor immunotherapy can benefit these patients is unknown, and Dr. Kim's work seeks to define the immune checkpoint pathways in FL - HCC.
cancerresearch.org
In the Medalist + C group, there were alterations in the DNA damage checkpoint pathway machinery that monitors the DNA repair process of the body's cells.
When the scientists reduced expression of miR200 in iPS and skin cells from the Medalist + C group, the DNA damage checkpoint pathway machinery was restored and DNA damage was reduced in the cells.
With the recent advances in immunotherapy that has entered the mainstream treatment of cancer, there is a critical need to investigate the immune checkpoint pathways in the tumor microenvironment of FLC, in order to understand if immune checkpoint inhibitors will benefit this group of patients.
A particular source of buzz was the second checkpoint pathway to be discovered, PD - 1.
These findings suggested that exhausted T cells are a distinct lineage of T cells in and of themselves instead of just being effector or memory T cells restrained by checkpoint pathways.
Microbes that cause diseases like HIV, malaria, and hepatitis C exploit and often activate the same checkpoint pathways — cell surface receptors such as CTLA4 and PD - 1 — to slow immune cells and prevent their elimination by the host.
One such checkpoint pathway is modulated by an enzyme called p38 mitogen - activated protein kinase (MAPK), whose activity is known to disrupt the cell cycle.
Abstract: In response to DNA lesions, human cells activate checkpoint pathways to repair DNA damage and prevent proliferation of genetically unstable cells.
PD - 1, which stands for programmed cell death 1, is the second immune checkpoint pathway currently being targeted with immunotherapies.
Zhang Y, Wolf GW, Bhat K, Jin A, Allio T, Burkhart WA and Xiong Y. Ribosomal protein L11 negatively regulates oncoprotein MDM2 and mediates a p53 - dependent ribosomal - stress checkpoint pathway.
In response, precancerous and cancerous cells may exploit immune checkpoint pathways to evade immune detection and destruction.
Checkpoint pathways are overcome by cancers when they fool the body's normal machinery into producing more cancerous cells.
With dementia, it turns out that the opposite is true: the Burnham team discovered that HIV / AIDS could co-opt the checkpoint pathway to prevent stem cells in the brain from dividing and multiplying.
Herrera's latest work builds upon phase 1 study results that he presented at the 2016 ASH meeting, measuring the safety of brentuximab vedotin — an antibody - based treatment that targets delivery of chemotherapy only to Hodgkin lymphoma cells — combined with nivolumab, which works by blocking something called the PD - 1 immune checkpoint pathway that tumors often hijack to evade the immune system.