Sentences with phrase «chemical approaches using»

The investigations are frequently combined with large scale perturbation methods, including gene - based (RNAi, miss - expression of wild type and mutant genes) and chemical approaches using small molecule libraries.

The yield of plutonium from this «electro - refining» is 10 times that of the chemical approach used in Europe, says William Hannum, research manager of the project.

Through the combination of a biological approach using various sugar - digesting enzymes and a chemical approach using synthetic sugars, the group succeeded in uncovering the active functional site on the plant's sugar chain.

Not exact matches

Embracing an organic winemaking approach, Domaine Vrignaud refrains from the use of fertilizers and chemicals, producing Chablis crafted with as little intervention as possible.

These approaches «do not tie the hand of growers against using all man - made chemical products in the vineyard,» notes Rebecca Sweet, who works for Oregon's LIVE.

The department gave two of its eight awards to these organizations this year to give rare public recognition to those who develop and promote methods for pest management that reduce the risks associated with using traditional chemical approaches.

HACCP is the preventive approach from the physical, chemical, biological hazards in production process and it is also used to ensure the food safe.

Our eight bee hives, located all around the farm, are maintained by Drumlin Farm beekeper Mel using an all - natural, chemical - free approach.

While there are specific Federal regulations that manufacturers must meet with regard to the chemicals used in raw materials, our approach has always been to not just meet, but to exceed, those regulations.

There are approaching 100,000 different human - made chemical compounds in use around the world today, and many of them harm humans and wildlife

The UMD and UMB team, led by research associate Eunkyoung Kim, used a discovery - driven approach based on the assumptions that chemical biomarkers relating to oxidative stress could be found in blood, and that they could be measured by common electrochemical instruments.

The researchers are using multidisciplinary approaches to make genetic modifications linked with all three traits, with the aim of improving sorghum for renewable energy and chemical production.

An easier alternative to the homemade approach is to use something well - known in an innovative way — a new assay based on a long - established and widely used chemical, for instance.

«A radical approach to methane oxidation into methanol: Researchers convert methane to valuable chemicals using clean, low - temperature radical reaction.»

From the vantage point of developing predictive design and formation approaches for synthetic materials, the observations suggest how chemical energy stored across adjacent regions with unequal distributions of dissolved molecules can use processes derived from biology to drive structural reorganizations for advanced functions.

The approach is limited because it only works in liquid reactions that start with polar chemicals and end with a nonpolar product, he says, but it's another tool that chemists could use to cut down on polluting waste.

«The approach should prove especially useful where it is not possible, or practical, to repair the material once it has been put to use,» writes University of Delaware chemical engineer Richard Wool in a commentary in Nature.

But alternative approaches, like capturing CO2 directly from the air using chemical reactions or absorbing it with ground - up minerals added to soils, are just beginning to see their first real - world tests.

In a bid to progress beyond the shotgun approach to fighting cancer — blasting malignant cells with toxic chemicals or radiation, which kills surrounding healthy cells in the process — researchers at the Harvard - MIT Division of Health Sciences and Technology (HST) are using nanotechnology to develop seek - and - destroy models to zero in on and dismantle tumors without damaging nearby normal tissue.

Described in a study published in the journal Nature Communications, this novel approach uses high - speed atomic force microscopy (AFM) combined with a CRISPR - based chemical barcoding technique to map DNA nearly as accurately as DNA sequencing while processing large sections of the genome at a much faster rate.

University of Wisconsin - Madison engineers have developed a new approach to structuring the catalysts used in essential reactions in the chemical and energy fields.

How can we spread this approach so we seriously cut back on the use of dangerous chemicals?

But Walter Nelson, director of helium sourcing and supply chain at Air Products and Chemicals Inc., in Allentown, Pennsylvania, testified that such an approach would be equivalent to Congress requiring one carmaker to let a rival use its factories so it wouldn't have to build its own.

This new approach, unveiled in this month's Nature Biotechnology, might be used to produce steroids — natural substances that can fight cancer and inflammation and are a key ingredient in some contraceptives — at a lower cost than traditional chemical synthesis.

In a 2013 study published in Neuron, McNamara's group showed this definitively by using a chemical - genetic approach to block TrkB signaling in a mouse briefly following an episode of prolonged seizures.

To put the pieces of the puzzle together, they combined three approaches previously not used together to reconstruct the ancient magma plumbing system by looking for chemical signatures in lava rock collected from flows on the surface.

The research team found that when a particular mitochondrial fission protein (GTPase dynamin - related protein - 1 — Drp1) was blocked using either gene - therapy or a chemical approach in experimental models of PD in mice, it reduced both cell death and the deficits in dopamine release — effectively reversing the PD process.

«While previous molecular studies have provided simple snapshots of the gene transcript variations that are associated with the exposure of insects to natural and synthetic chemicals, the genomics approaches used in this study offer a significantly more complex perspective on the biochemical and physiological processes occurring in plant - insect interactions,» Schuler said.

To pay for all the new approaches, the study's authors suggest raising fees for water use and charging fees for dam removal and chemical releases, among other things.

The new crystals were grown using an approach called template - assisted selective epitaxy (TASE) using metal organic chemical vapor deposition, which basically starts from a small area and evolves into a much larger, defect - free crystal.

The improved enzyme gave a 53 % increase in daily production volume and a 19 % reduction in total cost, as compared to the chemical approach conventionally used to synthesize sitagliptin.

The structural information is used for the rational design and development of small molecular inhibitors in combination with chemical biology approaches.

Using the approach, scientists exchanged one chemical group for another in 39 cancer drugs — and discovered under lab conditions that the chemically altered versions of three of the drugs had more potent anti-cancer activity.

Researchers in the University of Illinois School of Information Sciences used an informatics approach to identify the prevalence of chemicals in consumer products.

The approach adopted by the researchers is to decouple the supplied chemical energy from carbon fixation and to use it directly for chemical reactions.

So, could we go in and use targeted synthetic biology or chemical interference approaches to stop the production of methane?

To study these pathways, we use a range of in vitro and in vivo approaches, including manipulating genes in mice and leveraging genome - wide analyses and chemical biology.

Next we use such assays to identify LEAD chemical compound (s) with therapeutic potential for HD or to validate drug or gene - based therapeutic approaches developed by our collaborators (Pr.

An alternative approach, most common for anti-infectives, is to use compounds («phenotypic inhibitors») which have already been shown to be active against the target organism in the living pathogenic cell as chemical leads for improvement by Medicinal Chemistry, towards systemically active Candidate Drugs.

Our targeted profiling approach used a chemical derivatization of the 3 ′ hydroxyl group of the steroid A ring to form a sterol 3 - β - picolinate ester.

The advantages of this approach began to emerge in 2011, when Dr. Ding announced that he had used his «chemical reprogramming» method to convert human skin cells into brain cells.

Much of her work has examined this environmental justice question in the context of ambient air pollution and indoor chemical exposures, prenatal exposures and effects on birth outcomes and children's health, often using community - based participatory research approaches for data collection and risk communication.

«This interesting study in mice uses a chemical able to break down Alzheimer's plaques in the brain after they've already formed, potentially presenting a way to circumvent the difficult issue of timing with this treatment approach.

Validation of N - myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach.

Chemical proteomics includes affinity capture approaches using drugs / compounds as bait to study interacting proteins.

«A huge fraction of the human «proteome» remains uncharacterized, and this paper shows how chemical approaches can be used to uncover proteins of a given functionality that have eluded classification based on sequence or predicted structure,» said co-senior author Benjamin F. Cravatt, chair of TSRI's Department of Chemical Phychemical approaches can be used to uncover proteins of a given functionality that have eluded classification based on sequence or predicted structure,» said co-senior author Benjamin F. Cravatt, chair of TSRI's Department of Chemical PhyChemical Physiology.

University of Wisconsin — Madison engineers have developed a new approach to structuring the catalysts used in essential reactions in the chemical and energy fields.

Here we use a chemical genetics approach using knock - in mice in which either p38alpha or p38beta kinase has been rendered resistant to the effects of specific inhibitors along with p38beta knock - out mice to dissect the biological function of these specific kinase isoforms.

«Because nano - DESI already meets this trio of requirements in passive mode, the reactive mode is another valuable tool in understanding the complex chemical world around us,» said Dr. Alexander Laskin, an EMSL scientist who conducted numerous experiments using the reactive nano - DESI approach.

Then for postdoctoral research I moved to Yale University, where I worked in a lab that looked at all kinds of different disease areas using the approaches of a field called chemical biology, which is using small molecules — chemicals — to probe biological systems in the hopes of developing compounds that could be new drugs.