These closely related sisters have different jobs because of different
chemical tags on their DNA, researchers report.
A protein whose job it is to remove a specific kind
of chemical tag from other proteins.
A new study reveals that sperm carry
different chemical tags on their DNA depending on whether their owner is lean or obese.
A protein whose job it is to add a specific kind
of chemical tag to other proteins.
The experiment could be evidence that epigenetic marks —
chemical tags on DNA and proteins that change with age, experience, disease and environmental exposures — are a driving factor of aging.
The trick is methylation and demethylation — adding and removing
chemical tags called methyl groups to specific locations on DNA that turn genes on and off without editing the genetic code itself.
His experiments showed that Ataxin - 7 anchors one of the complex's enzymatic modules, which is responsible for
removing chemical tags called ubiquitin from DNA - packing proteins.
Together, the COMPASS proteins
add chemical tags called methyl groups to a component of a cell's DNA packaging machinery called a histone.
Ecker studies epigenetic processes in plants and animals, and is a leader in studies of methylation, in which
small chemical tags called methyl groups are attached to specific sites in the genome.
EARLY ERASER Sometime in the first trimester, human embryos» reproductive cells get wiped mostly clean of
chemical tags marking the DNA.
Compared with sons of control mice, their sperm had
fewer chemical tags known as methyl groups on about 110 stretches of DNA.
ENVIRONMENTAL EXPOSURES Things people come in contact with every day, such as pesticides, chemicals in water, hormone - mimicking chemicals in cash register receipts, smoke and air pollution, can
change chemical tags on DNA and proteins.
Could
such chemical tags help astronomers identify our own Sun's long - lost sibling stars?
Within the last decade, many scientists have come to believe that DNA methylation — a mode of genetic regulation in
which chemical tags turn genes on or off — is involved.
A microscopy image of the complete set of chromosomes in a 2 - cell stage mouse embryo
reveals chemical tags that, decorate, DNA - packaging proteins called histones.
This so - called epigenetic level of control is based on the localized, and in principle reversible, attachment of
simple chemical tags to specific nucleotides in the genome.
One aspect of gene regulation involves enzymes
placing chemical tags or modifications on histone proteins — which control a cell's access to the DNA sequences that make up a gene.
Before now, a lot of this epigenetic research had been done in yeast — single cell organisms that also use enzymes to
lay chemical tags on histone proteins.
Studies of embryonic stem cells revealed that NANOG protein levels can be lowered by a chemical process known as methylation, which involves putting a methyl
group chemical tag on a protein's messenger RNA (mRNA) precursor.
Although the H3K27M mutation disrupts a different
chemical tagging system, the scientists showed that panobinostat slowed the growth of a line of cells that had the mutation.
However, that method posed some challenges because it requires generating a
complicated chemical tag consisting of an antibody that targets a specific protein, linked to both a fluorescent dye and a chemical anchor that attaches the whole complex to a highly absorbent polymer known as polyacrylate.
Scientists have long used an imaging technique called positron emission tomography (PET) to visualize ß - amyloid deposits marked by
radioactive chemical tags in the brains of people with AD.
But some bacteria have evolved a counter strategy — injecting special proteins that suppress the plant's immune response by adding small,
disabling chemical tags called acetyl groups to immune molecules.
BODY MAP Researchers
mapped chemical tags on DNA in 111 different tissues and cells (including those pictured here).
«
Chemical tags affect ability of RNA viruses to infect cells: Similar controls found in Hepatitis, Zika, Dengue, Yellow Fever.»
Astronomers
use chemical tagging to try to identify stellar siblings even if they have drifted apart.
The test searches for evidence of so - called hypermethylation, a type of
chemical tag affixed to DNA in one or more of six breast cancer - specific genes.
The findings, published today in Nature Genetics, reveal a progressive, measurable loss of
specific chemical tags that regulate gene activity and are detectable at the earliest stages of development.
Several of these drugs block histone deacetylases, a group of enzymes that regulate genes by
removing chemical tags, called acetyl groups, from histone proteins.
Compared with people who had never smoked, these individuals had
fewer chemical tags known as methyl groups — a common type of epigenetic change — on 20 different regions of their DNA.
Epigenetic changes, such as
chemical tags called methyl groups attached to a gene, determine whether and how much of a gene is made into a protein.
Their results, published February 18 in the Proceedings of the Royal Society B, show that removing
chemical tags on a worker bee's DNA leads to aggressive bees that are more likely to lay eggs of their own.
Other molecular changes —
chemical tags added to DNA or to proteins called histones — may affect health without injuring DNA.
However, using an innovative method for the identification of factors capable of binding to and «reading»
the chemical tags that characterize unconventional DNA bases, Carell and colleagues have shown that stem cells contain specific proteins that recognize hydroxymethyluracil, and could therefore contribute to the regulation of gene activity in these cells.
FLAGGED A certain pattern of
chemical tags on DNA shows up more often in gay men than in straight men, a controversial study in twins suggests.
Instead, the genes have been switched off by the addition of
chemical tags called methyl groups.
During the screening process,
a chemical tag is added to the compounds of interest.
For example, a block could be prepared with
the chemical tag present, absent or mutated such that tagging can't occur.
One part of the enzyme, known as the chromodomain, is constantly exposed and seeks out specific
chemical tags, known as a methyl groups, located at predetermined sites on histones.