The researchers, funded by the Medical Research Council (MRC), the Wellcome Trust and Cancer Research UK, compared the effects of two cancer - causing
chemicals in normal mice and mice with the barrier defect (the knock - out mice).
Not exact matches
But unlike the
normal mice, those with altered macrophages showed no signs of inflammation, such as changes
in insulin production, high levels of immune
chemicals, and macrophages
in their belly fat.
When the Stanford team measured pyrophosphate levels
in cultured cells derived from ank and
normal mice, they found that the
chemical accumulated
in cells from the ank
mice but decreased
in the culture medium.
In mice, activating this region using targeted chemical genetic techniques resulted in prolonged wakefulness during the animals» normal sleep period
In mice, activating this region using targeted
chemical genetic techniques resulted
in prolonged wakefulness during the animals» normal sleep period
in prolonged wakefulness during the animals»
normal sleep periods.
Normal mouse oocytes are known to form parthenotes
in culture
in response to
chemical signals or temperature changes, but despite multiple attempts to implant them
in a womb, none has ever survived to birth.
Indeed, those
mice in Schwarzchild's study that were pretreated with caffeine retained near -
normal dopamine levels when exposed to a
chemical known to induce Parkinson's - like symptoms by decreasing brain dopamine.
In one memory test included in the study, normal mice were able to relocate a submerged platform about three times faster after receiving injections of the potent chemical than mice that received sham injection
In one memory test included
in the study, normal mice were able to relocate a submerged platform about three times faster after receiving injections of the potent chemical than mice that received sham injection
in the study,
normal mice were able to relocate a submerged platform about three times faster after receiving injections of the potent
chemical than
mice that received sham injections.
The antibodies used
in this study includes COX - 2 (Cayman
Chemicals, Ann Arbor, MI, USA), STAT6 for Western blot (Cell Signaling Technology, Danvers, MA, USA), for immunofluorescence (IF)(BD Pharmingen, San Diego, CA, USA), for ChIP (Santa Cruz Biotechnology, Santa Cruz, CA, USA), phospho - STAT6 (Cell Signaling Technology), p300 for Western blot, (Upstate, Lake Placid, NY, USA), for ChIP (Santa Cruz Biotechnology),
normal rabbit IgG (Santa Cruz Biotechnology),
mouse immunoglobulin (Ig) G1, κ Ig (BD Pharmingen), glyceraldehyde -3-phosphate dehydrogenase (Advanced ImmunoChemical, Long Beach, CA, USA), Cy3 - conjugated AffiniPure Goat anti-
mouse IgG (Jackson ImmunoResearch, West Grove, PA, USA) and PARP (Cell Signaling Technology).