Sentences with word «chemoattractant»

Curcumin likewise suppresses production of monocyte chemoattractant protein - 1 (MCP - 1), interferon - inducible protein, tumor necrosis factor (TNF), and interleukin - 12 (I...

Curcumin likewise suppresses production of monocyte chemoattractant protein - 1 (MCP - 1), interferon - inducible protein, tumor necrosis factor (TNF), and interleukin - 12 (IL - 12), cytokines which recruit or activate immune cells and perpetuate pro-inflammatory immune cascades (Chainani, 2003).

To better determine the role of specific chemoattractants in type III hypersensitivity, lead author Yoshishige Miyabe, MD, PhD, a research fellow in Luster's lab, used multiphoton intravital microscopy — an imaging technology pioneered for studies of immune cell movements in living animals by CIID investigator and co-author Thorsten Mempel, MD, PhD — to follow in real time the development of IC - induced arthritis in a mouse model of rheumatoid arthritis.

«But when the disease has become symptomatic, it is difficult to determine the initial steps that set off the recruitment of immune cells into the joint and the specific roles of the different chemoattractants.

Once the inflammatory process has been initiated, neutrophils within the joint space release interleukin - 1, which induces cells lining the joint space to produce chemoattractants called chemokines that further facilitate the movement of neutrophils into the joint space.

«Inflammatory arthritis is caused when immune cells are recruited from the blood into the joint in a highly regulated process controlled by chemoattractants and adhesion receptors,» says Andrew Luster, MD, PhD, chief of the MGH Division of Rheumatology, Allergy and Immunology, director of the CIID and senior author of the report.

In addition to its role in development, the CXCR4 - CXCL12 axis is a potent CD4 + T cell chemoattractant, and the broad expression of both proteins suggests that this axis may play a fundamental role in basal chemotaxis as opposed to a response to inflammation [52].

The lymphocyte chemoattractant SDF - 1 is a ligand for LESTR / fusin and blocks HIV - 1 entry.

These data add to a series of findings showing how differential responsiveness to chemoattractants emanating from adjacent zones determines cell position (Reif et al., 2002; Cyster, 2005; Bromley et al., 2008).

ChemoCentryx, Inc. is a clinical - stage biopharmaceutical company, which focuses on discovering, developing and commercializing orally - administered therapeutics that target the chemokine and chemoattractant systems in order to treat autoimmune diseases, inflammatory disorders and cancer.

Additionally, two inflammation markers were determined, namely, the expression levels of cyclooxygenase 2 and the levels of secreted monocyte chemoattractant protein - 1.

In a new study published in November in Scientific Reports, New York University College of Dentistry (NYU Dentistry) researchers investigating the catabolic effect of parathyroid hormone (PTH) in hyperparathyroidism (HPT) showed, for the first time, that monocyte chemoattractant protein - 1 (MCP - 1) is required for catabolic responses to PTH.

Damaged mouse sciatic nerves produced hundreds of times the normal amount of two «chemoattractant» molecules, Cxcl1 and Cxcl2, which attach to the surfaces of neutrophils and draw the immune cells into injured tissue.

«Imaging of the joint could help evaluate the mechanism of a drug's therapeutic effect, and if a process turns out to be mediated by more than one chemoattractant, understanding the mechanism would allow the rational design of combination therapies to completely shut down critical steps in the process.»

The end of the maze was loaded with high concentrations of a chemical the cells would sense and home toward (known as a chemoattractant), and the concentration of the chemical gradually waned across the maze, forming a gradient that the racing cells would need to read and follow, moving from low concentration to high.

Polleux F., Morrow T. and Ghosh A. (2000) Semaphorin 3A is a chemoattractant for cortical apical dendrites.

These factors include chemokine (C - X-C motif) ligand 12 (CXCL12), a chemokine produced by bone marrow mesenchymal cells that functions as a chemoattractant and survival factor for cells bearing the chemokine (C - X-C motif) receptor 4 (CXCR4), and insulin - like growth factor 1 (IGF - 1), a factor that is stored in the bone matrix and released during osteolysis (28).

Semaphorins are a class of proteins that have been shown to play a role in dendritic growth in a wide variety of species, working as either a chemoattractant or chemorepellant in guiding growth of dendrites during development.

Non-Classical Monocytes and Monocyte Chemoattractant Protein - 1 (MCP - 1) Correlate with Coronary Artery Calcium Progression in Chronically HIV - 1 Infected Adults on Stable Antiretroviral Therapy.

Monocyte chemoattractant protein - 1 (MCP - 1) plays an important role in the development of allergic inflammatory reactions by recruiting various immune cells, which is associated with many autoimmune diseases, but the association with the MCP -1-2518A / G gene polymorphism and lupus nephritis...

Monocyte chemoattractant protein - 1 (MCP - 1) is a key protein mediating inflammatory processes.

To address these issues, we developed a microfluidic device to monitor the behaviour of cells embedded in a 3D collagen matrix in the presence of complex concentration fields of chemoattractants.

C3G significantly upregulated the glucose transporter 4 (Glut4) and downregulated RBP4 in the white adipose tissue, which is accompanied by downregulation of the inflammatory adipocytokines (monocyte chemoattractant protein - 1 and tumor necrosis factor - alpha) in the white adipose tissue of the C3G group.

White adipose tissue messenger RNA levels and serum concentrations of inflammatory cytokines (tumor necrosis factor - α, interleukin - 6, and monocyte chemoattractant protein - 1) were reduced by C3G, as did macrophage infiltration in adipose tissue.