Sentences with phrase «chemotherapeutic agents»

The interstitial pressure inside a tumor is often remarkably high compared to normal tissues and is thought to impede the delivery of chemotherapeutic agents as well as decrease the effectiveness of radiation therapy.

Also, it is currently in clinical trials in combination with other chemotherapeutic agents for the prevention of growth and metastasis of a number of cancers including glioma [121], acute myeloid leukemia (AML)[122], chronic lymphocytic leukemia (CLL)[123].

To the best of my knowledge there is not a very successful hemotherapeutic or radiation protocol for this cancer at this time but dogs treated with chemotherapeutic agents do live a little longer than dogs that do not receive this treatment.

Assists in preparing and labeling of intravenous medications including total parenteral nutrition products and chemotherapeutic agents using proper sterile and aseptic technique.May perform quality control activities such as monthly nursing unit inspections and pharmacy section checks in a timely manner.

The fact that four of the drugs used in the tests — heparin, cytochalasin D, ethyl - isopropyl amiloride and choloroquine — are already approved by the Food and Drug Administration for other uses suggests that they may also be useful as chemotherapeutic agents, Nagrath said.

After frustrating decades of little progress, the landscape of melanoma therapy was dramatically altered with the first report in 2010 of significantly improved overall survival with the cytotoxic T - lymphocyte — associated antigen 4 (CTLA - 4) inhibitor ipilimumab, compared with a vaccine, and subsequently, compared with the then «standard» chemotherapeutic agent dacarbazine (DTIC).

Banerjee S, Wang Z, Kong D et al. 3,3» - Diindolylmethane enhances chemosensitivity of multiple chemotherapeutic agents in pancreatic cancer.

A major breakthrough in the treatment of cancer was the development of multiple chemotherapeutic agents (known as combination chemotherapy).

The established method of treatment is the use of a combination of various chemotherapeutic agents.

No targeted therapy has been approved for noninflammatory and inflammatory triple - negative breast cancer tumors, and the standard of therapy for these tumors is a combination of conventional cytotoxic chemotherapeutic agents.

And chemotherapy is not very effective because most chemotherapeutic agents don't pass out of the bloodstream into the brain.»

Rehemtulla adds that if other FDA - approved chemotherapeutic agents reach their targets as successfully as Photofrin did, «then we will have developed a way to make cancer drugs more «tumor - specific,» because they will only get into tumor vasculature and not normal vasculature.

Dogs that are receiving antibiotic therapy or any other chemotherapeutic agent for bacterial infections can also benefit from the anti-inflammatory properties of Temaril P. Antibiotics effectively kill the causative bacterial organism while Temaril P can help in the reduction of the inflammatory processes secondary to bacterial infections in canines.

At the same time they are very resistant to the conventional chemotherapeutic agents.

BMH - 21 also appears to overcome the tendency of cancer cells to resist chemotherapeutic agents because it finds and targets proteins and shuts down the communication pathways that cells use to continue dividing.

To make this discovery, researchers treated breast cancer cells with a common chemotherapeutic agent.

«We have evidence that the stem cells did in fact convert the prodrug to an active chemotherapeutic agent in the brain,» says Karen Aboody, the translational researcher at City of Hope who developed the therapy.

In addition to validating these cells, the group has determined the sensitivity of these cell lines to a variety of chemotherapeutic agents currently in use and proposed for use in the treatment of canine cancers.

A related research paper on the role of chemotherapeutic agents on regulating protein methylation, also from the Li lab, will be published in the June 7th issue of Molecular Cell, and is now online.

More importantly, the researchers found that while chemotherapeutic agents targeting each subtype achieve modest efficacy alone, they are synergistic when combined as demonstrated in a mouse model.

Astrocytes upregulate survival proteins in cancer cells which protect those cells against chemotherapeutic agents such as temozolamide.

Repurposing the FDA - approved pinworm drug pyrvinium as a novel chemotherapeutic agent for intestinal polyposis.

Given the apoptosome's critical role in the execution of stress - induced apoptosis, these studies provide key insights into the mechanisms by which many, if not most, chemotherapeutic agents induce cell death.

An ideal chemotherapeutic agent is expected to specifically kill tumor cells, cause the least amount of undesirable side effect, and leave normal cells unharmed.

The Broad team, lead by Piyush B. Gupta, screened some 16,000 chemicals, including all known chemotherapeutic agents approved by the F.D.A..

This study clarifies the signaling pathway that induces p53 via ActD, a potential chemotherapeutic agent.

Overholser and colleagues discuss the role of endocrine therapy to reduce risk for breast cancer, and cite interesting data from patients who developed premature ovarian failure due to ovarian irradiation or alkylating chemotherapeutic agents, which demonstrates that these patients were at decreased risk for developing subsequent breast cancer.

Although the specific compounds in the extract that were responsible for this effect have yet to be determined, what the study showed for certain was that the dandelion root extract used performed as a «natural chemotherapeutic agent», as the study authors have put it.

On the way home, with a sack containing a total of six medications Quin» C would be on, including the powerful chemotherapeutic agent, Palladia, we did a bounce - back visit to the same Zips and ordered the same menu items.

If the dog's condition does not improve, stronger immunosuppressive drugs, including chemotherapeutic agents, can be added to the mix.

The Foundation's Osteosarcoma Initiative is funding several active studies all focused on various aspects of osteosarcoma, from personalized medicine to innovative chemotherapeutic agents.

Many chemotherapeutic agents impair the bone marrow's ability to produce cells.

Clinical studies examining the efficacy of the systemic chemotherapeutic agent Tamoxifen (a drug often given to women with breast cancer) for advanced mammary cancer in dogs has shown no measurable therapeutic gain in any of the dogs within the study.

Therapy centers on immunosuppressive doses of steroids and sometimes the use of additional chemotherapeutic agents.

Due to advances in veterinary medicine, tests can be applied to mast cell tumor biopsy samples to determine if certain chemotherapeutic agents should be used for treatment.

Must have IV sterile compounding experience and able to admix chemotherapeutic agents for IV infusion.

Title of thesis: «Study of the pro-apoptotic effect of histones deacetylases inhibitors, used alone and concurrently with chemotherapeutic agents, on human lung cancer cells».

Avoid kidney - damaging drugs such as aminoglycoside antibiotics, methoxyflurane anesthesia, various chemotherapeutic agents, sulfonamide antibiotics, etc..

The compound (right panel) has a scorpion - like shape with two arms grabbing EphA2 - expressing cancer cells, and a tail (brown) constituted by a cytotoxic chemotherapeutic agent (paclitaxel used in this work).

Paradox Pharmaceuticals Inc. of Memphis, Tennessee: chemotherapeutic agent for use in companion animals to overcome drug resistance.

To protect infant health, the American Academy of Pediatrics does not recommend breastfeeding for women receiving certain drugs, including diagnostic or therapeutic radioactive isotopes or exposure to radioactive materials, antimetabolites or chemotherapeutic agents, and current use of drugs of abuse (4).

Written by world - renowned Clinical Pharmacologist, Dr. Thomas Hale, and assisted by Dr. Hilary Rowe, this drug reference provides everything that is known about the transfer of various medications into human milk, the use of radiopharmaceuticals, the use of chemotherapeutic agents, and vaccines in breastfeeding mothers.

You shouldn't nurse if you are receiving radiation in any form or are taking medications that pass into the breast milk and can hurt the baby, like antithyroid medication, chemotherapeutic agents, and some mood - altering drugs.