Sentences with phrase «chemotherapy agents in»
In the study, the researchers tested phenformin as a chemotherapy agent in genetically - engineered mice lacking LKB1 and which had advanced stage lung tumors.
https://www.salk.edu/ Not exact matches
«We remain committed to advancing our IDO pathway inhibitor indoximod, which continues to generate exciting data in combination with anti-PD-1 agents, cancer vaccines, and chemotherapy in multiple cancer types including melanoma, prostate cancer, acute myeloid leukemia, and pancreatic cancer.»
Persin, a natural toxin found in avocados, appears so effective at killing breast cancer cells that it is being considered as a chemotherapy agent.
Treatment of APL requires cycles of multiple therapeutic agents, including chemotherapy, in three distinct phases: induction, consolidation, and maintenance.
A New York patient is now the second U.S. citizen to be infected with bacteria carrying a «superbug» gene, according to findings published earlier this week in the journal for Antimicrobial Agents and Chemotherapy.
A major breakthrough in the treatment of cancer was the development of multiple chemotherapeutic agents (known as combination chemotherapy).
When 2 years ago Hackett discovered a new way of using a lipid to link drugs to the soluble protein albumin, and that the combination showed promise in improving the bioavailability of the chemotherapy agent paclitaxel, he and his adviser thought they had an invention that laid the foundation for a company.
«The network recognizes patterns,» says M. Rizwan Sohail, an infectious disease expert at Mayo Clinic and lead author of the study, presented at the Interscience Conference on Antimicrobial Agents and Chemotherapy in San Francisco in September.
In multiple preclinical models, OMP - 54F28 (FZD8 - Fc) has shown its effectiveness in reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined with chemotherapIn multiple preclinical models, OMP - 54F28 (FZD8 - Fc) has shown its effectiveness in reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined with chemotherapin reducing CSC populations, leading to associated anti-tumor activity, either as a single agent or when combined with chemotherapy.
The findings, announced online in the journal Antimicrobial Agents and Chemotherapy and funded by the National Institutes of Health, provide a needed boost to the field of antibiotic development, which has been limited in the last four decades and outpaced by the rise of drug - resistant bacterial strains.
Research has previously shown that veliparib is effective in combination with chemotherapy, but little data was available to indicate whether veliparib was effective as a single agent.
Intermittent dosing with rapamycin selectively breaks the cascade of inflammatory events that follow cellular senescence, a phenomena in which cells cease to divide in response to DNA damaging agents, including many chemotherapies.
New research presented at the American Society of Clinical Oncology (ASCO) 53rd Annual Meeting in Chicago shows that a previously untested combination of a monoclonal antibody - drug conjugate with a common chemotherapy agent has a high complete - response rate in children and young adults with relapsed or refractory Hodgkin lymphoma.
The study will be published in the January 2014 issue of Antimicrobial Agents and Chemotherapy.
The research is published in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.
Antibiotic resistance is increasing due to the over prescription of antibiotics, said Ashok Chopra, a professor at UTMB and author of the new study in the Journal of Antimicrobial Agents and Chemotherapy.
«Given development times and manufacturing requirements for new products, repurposing of existing drugs is likely the only solution for outbreaks due to emerging viruses,» the investigators noted in the paper now online in the journal Antimicrobial Agents and Chemotherapy.
In future, Bandyopadhyay says, better understanding how chemotherapy agents impact specific biological pathways should allow drug trials to focus on patients who are more likely to respond to the drugs being tested and enable clinicians to identify targeted or combination therapies for patients with a genetic predisposition to resistance.
Researchers from NIH's National Institute of Allergy and Infectious Diseases (NIAID) presented the preliminary study results at the Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) meeting in Denver in September 2013.
They confirmed this by showing that tumor growth was reduced in mice treated with an antibody drug that targets TIM - 3 and the chemotherapy agent paclitaxel, as compared to treatment with paclitaxel alone.
The study was posted online and will appear in print in the American Society for Microbiology's journal Antimicrobial Agents and Chemotherapy in April.
«This paper reveals a metabolic frailty in cancer cells that is based on their own production of oxidizing agents that allows us to utilize existing redox active compounds, like vitamin C, to sensitize cancer cells to radiation and chemotherapy,» says co-author Garry Buettner, who was one of the first to propose that cancer cells might have a vulnerability to redox active compounds over 40 years ago.
The National Institutes of Health - supported discovery will be described in the June issue of the journal Antimicrobial Agents and Chemotherapy.
When used alongside standard chemotherapy agents daunorubicin and cytarabine in a treatment - resistant AML model, 99.7 percent of cancer cells were killed.
She presented the research, conducted by scientists from the University of Lisbon in Portugal, June 20 at a joint meeting of the American Society for Microbiology and the Interscience Conference on Antimicrobial Agents and Chemotherapy.
The research was published in the June 2013 issue of the journal Antimicrobial Agents and Chemotherapy.
A similar antibody - drug conjugate approach is used by the breast cancer agent T - DM1, which attaches chemotherapy to an antibody that seeks the HER2 protein in HER2 + breast cancers.
Findings of the study published in June in the journal Antimicrobial Agents and Chemotherapy, which is published by the American Society of Microbiology.
Chemotherapy delivered via the placement of a central venous line that remains in place for the duration of treatment can result in pre-operative thromboembolic events, which can require the administration of anticoagulation agents.
Researchers used the mice to show that pemetrexed and gemcitabine worked against human group 3 tumors and that the drugs could be used in combination with existing chemotherapy agents to boost treatment effectiveness without undue risk.
The research is published this week in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.
The research is published July 11, in Antimicrobial Agents and Chemotherapy, a journal of the American Society for Microbiology.
«Importantly, two chemotherapy agents — methotrexate and cyclophosphamide — could be dosed to completely reverse obesity without detectable toxicity, even in mice without cancer,» explains Dr. Myers.
At the Interscience Conference on Antimicrobial Agents and Chemotherapy in Chicago, Illinois, this weekend, researchers reported preliminary results from tests of a novel treatment in 15 HIV - infected people designed to free them from the need to take antiretroviral drugs.
Furthermore, the agent prevented the drop in the number of neutrophils (i.e., neutropenia) found in the blood that is typically caused by 5 - fluorouracil, a chemotherapy agent commonly used in the treatment of gastrointestinal and other tumors, such as colon, stomach, pancreas and breast cancers.
Nichol's colleagues presented the results on Sunday at the Interscience Conference on Antimicrobial Agents and Chemotherapy in Chicago.
It is also used in some cancers at much higher doses where the side effects are substantial and similar to other chemotherapy agents.
The vaccine was tested in a preliminary clinical trial and used with standard chemotherapy and an immune - boosting agent.
In the research, Rieger treated the zebrafish with pharmacological agents that reduce MMP - 13 activity, with the result that skin defects were improved and chemotherapy - induced nerve damage was reversed.
For a majority of patients diagnosed with aggressive, high - grade tumors with metastases, the five - year survival rate is about 16 percent, though chemotherapy has been associated with an improvement in survival, and new targeted agents are being tested.
The agent was previously approved in December 2016 for the treatment of ovarian cancer specifically associated with BRCA mutations, in women who had received at least two prior chemotherapy regimens.
Therefore several trials previous published have as an exclusion criterion atelectasis, pleural effusion and tumor mass more than 5 cm of diameter.8 The rest of the criteria remain the same as in the case of intravenous infusion, renal function, blood values and performance status have to be appropriate according to the NCCN guidelines.38 Moreover; the administered drug has to be safe in order to be provided as aerosol, several chemotherapy agents have been reported to be toxic for the lung parenchyma.
The structure of these transporters is essential to the rational design of agents which control their function.30 - 32 In our current work we investigated the chemotherapy agent cisplatin since it the most used chemotherapy drug for a number of cancer types and the application would have an impact on several cancers.
The immunotherapeutic agent Ipilumumab has been shown to have a markedly positive effect in the treatment of patients who are resistant to conventional hormone treatments and chemotherapy.
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The use of two drugs never tried in combination before in ovarian cancer resulted in a 70 percent destruction of cancer cells already resistant to commonly used chemotherapy agents, say researchers at Mayo Clinic in Florida.
The adverse prognostic effect of histone modifier gene mutations was further proven in a chemotherapy - independent manner, prompting us to explore bio-therapeutic agents that can overcome chemoresistance in PTCL - NOS patients.
Study of the effect of valproate on pulmonary cancer cells, in combination with chemotherapy agents.
Kvansakul found that the viral protein blocks multiple pro-apoptotic proteins in host cells, and that in a mouse model of Burkitt lymphoma it also renders chemotherapy agents ineffective, making it a potent oncogene.
Researchers note that while PCI - aided delivery of chemotherapy to the brain has proven effective in laboratory tests, additional testing prior to human clinical trials is needed to identify other less - toxic blood - brain barrier agents to be used in tandem with the photosensitizer in the PCI process.