Sentences with phrase «chemotherapy at dose»
The case involved a 43 year old breast cancer patient who was receiving chemotherapy at dose administered 80 % higher than the standard.
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Chemotherapy drugs are usually administered to cancer patients every few weeks at a high «maximum tolerated» dose.
Conventional, high - dose chemotherapy treatments can cause the fibroblast cells surrounding tumors to secrete proteins that promote the tumors» recurrence in more aggressive forms, researchers at Taipei Medical University and the National Institute of Cancer Research in Taiwan and University of California, San Francisco, have discovered.
Frequent, low - dose chemotherapy regimens avoid this effect and may therefore be more effective at treating certain types of breast and pancreatic cancer, according to the murine study «Metronomic chemotherapy prevents therapy - induced stromal activation and induction of tumor - initiating cells,» which will be published online November 23 in The Journal of Experimental Medicine.
A third group of mice received the standard high dose of chemotherapy at first, but once the animals» tumours started to shrink, the researchers dialled back the dose.
Because AML is difficult to treat, standard treatment commonly involves multiple chemotherapy medicines that are given at a higher dose in order to kill the cancer cells.
The safety study sets the stage for phase II clinical trials looking at whether high dose vitamin C is effective at extending overall lifespan and quality of life for patients undergoing radiation and chemotherapy.
Treating patients with high - dose radiotherapy after chemotherapy and surgery for malignant pleural mesothelioma does not achieve improvements in local relapse and overall survival, according to data from a prospective randomized phase II trial presented at ESMO 2014 Congress in Madrid.
This therapeutic effect was enhanced by combining the Angiopoietin - 2 antibody with a so - called metronomic chemotherapy: In this kind of therapy, chemotherapeutic drugs are given continuously at much lower dose as in the classical high - dose chemotherapy.
«Mesothelioma remains a difficult disease to find better treatment options for, so we asked whether high - dose hemithoracic radiotherapy would decrease the rate or delay the time of local recurrence after chemotherapy and radical surgery,» says lead author Prof Rolf A. Stahel, from the Clinic and Policlinic for Oncology, at the University Hospital Zurich, Switzerland, and current President of the European Society for Medical Oncology.
Methotrexate is already used as a chemotherapy drug for several types of cancer, and this early research shows that at much lower doses it could have the potential to help treat certain blood disorders.»
It is also used in some cancers at much higher doses where the side effects are substantial and similar to other chemotherapy agents.
Those with uninformative cytogenetic or molecular markers with negative minimal residual disease at the end of induction were noted to experience the most benefit (nearly 2-fold benefit from receiving a fifth dose of chemotherapy) vs. those with favorable cytogenetic and molecular features who did not experience benefit from receiving a fifth dose of therapy.
DNA interstrand crosslinks (ICLs) are highly toxic DNA lesions that can form endogenously but are also induced at high doses in cancer chemotherapy.
Many studies have shown that at high doses, vitamin C is toxic to cancer cells, able to work synergistically with conventional therapies such as chemotherapy and radiation.
In fact at the doses used, the chemotherapy is not having direct cytotoxic activity, i.e. not directly killing the cancer cells.
Metronomic chemotherapy is a low dose at high frequency that lowers toxicity and is aimed at the tumor.
She has since undergone surgery at B.C. Children's Hospital to remove a tumour, but Paige still needs to receive high dose chemotherapy treatment for the next six to eight months.