To aid research into potential new treatments, Jane Wilson and Natalie Prow of QIMR Berghofer Medical Research Institute, Australia, and colleagues exploited an adult wild - type mouse model of
chikungunya virus infection and diseases previously developed by the group.
Locally acquired cases
of chikungunya virus have been identified in the US for the first time, while cases soar in Europe and Central America
Exploring further, the scientists showed that mice missing the granzyme A gene, when infected
with chikungunya virus, experienced dramatically less foot swelling and arthritis.
Chikungunya Symptoms: The symptoms of
chikungunya in children include fever, rash, severe headaches, chills, nausea and vomiting, severe pain in the joints, and diarrhea.
A VACCINE that masquerades
as chikungunya virus might finally defeat the mosquito - borne disease.
There are two top vaccine candidates
for chikungunya right now, but neither has completed the rigorous testing required before they would be available to patients.
A female Aedes aegypti mosquito, one of the two species that
spreads chikungunya virus, is shown feeding.
Acute
chikungunya fever typically lasts a few days up to a few weeks, but some patients experience prolonged fatigue and pain lasting several weeks.
Scientists looking at the antiviral mechanisms of two previously identified human monoclonal antibodies have found they potently
inhibit chikungunya virus (CHIKV) at multiple stages of infection.
Insect - spread
disease chikungunya is on the rise — and has now made its way from Africa to the USA.
Aedes albopictus is one of two mosquito species that
transmit chikungunya virus, recently reported in the United States.
«Our mission is to ensure the safety of the world's blood supplies and to prevent the transmission of viruses
like chikungunya through blood transfusions,» explains Dr. Michael Busch, senior vice president and director of BSRI.
In 2010, Vaccine Research Center (VRC) scientists and colleagues tested this candidate
chikungunya vaccine in non-human primates.
Carrie Manore of the Laboratory's Theoretical Biology and Biophysics group and a team developed a mathematical model informed by field data to assess the conditions likely to facilitate local transmission of the Zika and
chikungunya arboviruses from an infected traveler to the tiger mosquito and then to other people in cities in the eastern United States.
The tests so far show strong evidence that mosquitoes can pick up and transmit Zika and
chikungunya simultaneously — something that had not been confirmed before, given the recent arrival of Zika in the Americas.
«Mouse study reveals potential drug target for arthritis caused
by chikungunya virus: A specific immune system proteinase may promote arthritic inflammation after viral infection.»
Investigators
detected chikungunya neutralizing antibodies in all volunteers following the second injection, with a significant boost of neutralizing antibodies seen following the third injection.
The four Zika cases in Miami have triggered far more attention than the cases of local dengue and
chikungunya transmission, Fauci says.
Sometime in late 2013, a mosquito - borne virus
called chikungunya appeared for the first time in the Western Hemisphere.
This assay is a useful tool for detection of ZIKV infection in regions where a number of other clinically indistinguishable arboviruses like dengue or
chikungunya co-circulate.
«Impacts of vector abundance and weather on risk of dengue and
chikungunya incidence across Kenya» presented by Amy Krystosik
He or she may order a blood test to confirm the diagnosis, as dengue and
chikungunya exhibit similar symptoms.
Although most of the U.S. citizens caught the virus abroad, on July 17, a Florida man became
first chikungunya victim to contract the virus at home.
But the type of
chikungunya creeping across the region then was one that could only readily spread via Aedes aegypti, a mosquito that is uncommon in the U.S..
A second form of the
painful chikungunya virus has appeared in Brazil — one that could more easily spread, including to the U.S.
Blood banks begin using the method in donations this summer as the northward spread of chikungunya continues
An experimental vaccine to prevent the mosquito - borne viral
illness chikungunya elicited neutralizing antibodies in all 25 adult volunteers who participated in a recent early - stage clinical trial conducted by researchers at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
Scott Weaver, a virologist at the University of Texas Medical Branch in Galveston, notes that in places
where chikungunya immunity was measured, «typically from 20 to 50 percent of the population became infected as the outbreak swept through a given region.»
«Most of them will not lead to local transmission, but our experience with dengue and
chikungunya tells us that some of them probably will.»
The study also suggested that granzyme A could serve as a potential target for new drugs to
treat chikungunya and related viral arthritides in people.
«Although a
different chikungunya virus strain from the Asian lineage is now circulating in the Americas, the introduction of the Indian Ocean lineage could put temperate regions where A. albopictus thrives at risk for expansion of epidemic circulation,» Weaver cautioned.
«Since there is no vaccine to
prevent chikungunya and no medicine to treat it, people who are traveling to these areas should be aware of this infection and take steps to avoid mosquito bites, such as wearing repellent and long - sleeves and pants if possible,» said study author Patrick Gérardin, MD, PhD, of Central University Hospital in Saint Pierre, Reunion Island.
When Armstrong's team analysed the data, they found no link
between chikungunya infections and birth rates.
Over the past couple of years, the Crowe lab has produced human monoclonal antibodies that can neutralize, or kill, a wide range of potentially lethal viruses,
including chikungunya, dengue, Ebola, and its close cousin, Marburg.
They conclude,» [r] ecent epidemics were surprises — Zika and
chikungunya sweeping through the Americas; an Ebola pandemic with more than 10,000 deaths; the emergence of severe acute respiratory syndrome and Middle East respiratory syndrome, and an influenza pandemic (influenza A [H1N1] pdm09) originating in Mexico — and we can be sure there are more surprises to come.
To participate in the challenge, researchers must make a submission every month, guessing how
many chikungunya cases will occur over the remainder of the 6 - month competition in each of the 35 member countries of the Pan American Health Organization.
To better
understand chikungunya infection rates in the blood supply, BSRI, in collaboration with the U.S. Centers for Disease Control, Puerto Rico Blood Banks, Creative Testing Solutions and Hologic, a company that manufactures blood screening assays, recently completed a large study that documented very high rates of infected donations during the 2014 outbreak in Puerto Rico which infected nearly 25 % of the territory's population.
Once considered a disease of developing countries in African and Asia,
chikungunya got a burst of scientific attention when it popped up on the French island of La Reunion in 2007.
«But for
chikungunya specifically,» continues Simmons, «more research is still needed to know whether the virus can be transmitted via blood transfusion and if the recipient of the infected blood develops symptoms.»
BSRI, together with colleagues in the Recipient Epidemiology and Donor Evaluation Study - III Brazil team and Hologic, also recently received supplemental funding from the National Heart, Lung and Blood Institute of the National Institutes of Health to conduct a study in São Paolo, Brazil, to establish whether transfusion transmission of
chikungunya occurs, and if so, the clinical consequences of infection in transfusion recipients.
In light of these recent events, researchers from IRD and the CIRMF in Gabon restarted work on the concomitant dengue and
chikungunya epidemic that occurred in 2007 in the capital, Libreville, and which affected 20,000 people.
Rapid expansion of this species, which is more aggressive than the species that is now spreading
chikungunya into the Caribbean, is worrying scientists
He took the
original chikungunya strain circulating in Kenya and infected a group of Asian tiger mosquitoes with it.