Sentences with word «chimeric»

Aside of conventional bispecific antibodies and antigen specific chimeric antigen receptors (CARs) for retargeting of T cells e. g. to prostate cancer or leukemic cells we have developed a novel and unique modular cell targeting system allowing us to target any kind of antigen.

The CD31 antibody - reactive cells (red, A and E) and AFP antibody - reactive cells (red, I and M) were detected specifically in the liver of chimeric mice from iPS cells of line 11.1.

Summer and fall brought approval of chimeric antigen receptor (CAR) T - cell therapies for forms of leukemia and lymphoma.

T - cells can be programmed to recognise these by giving them genes for tailor - made receptors called chimeric antigen receptors (CARs).

Allogenic allografts in chimeric mice were harvested on either day 40 or day 100 - post transplantation.

Although the T cells of chimeric animals responded to alloantigen, the response was similar to that of non-chimeric control animals, suggesting that these cells did not appear to lead to deletion of alloreactive T cells.

In mice whose brainstems were implanted with human DIPG, engineered immune cells known as chimeric antigen receptor T cells — or CAR - T cells — were able to eliminate tumors, leaving very few residual cancer cells.

The technology is called Chimeric Antigen Receptor T - cell therapy (CAR - T), which uses a patient's own immune cells to fight cancer.

Trianni has the leading chimeric human mouse for generation of fully human antibodies.

However, when challenged to differentiate immediately after purification, each exhibits strong lineage bias, with the endoderm marker - expressing fraction unexpectedly able to contribute to the extra-embryonic endoderm in chimeric embryos.

In therapy, a patient's T cells are removed and engineered to express chimeric antigen receptors (CARs), which specifically target proteins expressed by cancer cells.

Santa Monica, California - based Kite is developing chimeric antigen receptor T - cell therapy, known as a CAR T, which harnesses the body's own immune cells to recognize and attack malignant cells.

Dr. June: I'm working with CAR T cells — CAR stands for chimeric antigen receptor.

And because pigs are genetically closer to humans than mice are, success in creating chimeric pigs from stem cells offered renewed hope that the technology could lead to better pharmaceutical testing or stem cell therapies.

The pluripotent properties of ES cells can be demonstrated by in vitro differentiation or by reintroduction of these cells back into chimeric embryos by blastocyst injection or morula aggregation.

To examine antigen processing and presentation in vivo, we specifically targeted antigens to two major subsets of DCs by using chimeric monoclonal antibodies.

This is a schematic of how a «chimeric autoantibody receptor,» or CAAR, that displays fragments of the autoantigen Dsg3 helps fight an autoimmune disease called pemphigus vulgaris, a condition in which a patient's own immune cells attack Dsg3, which normally adheres skin cells.

Third - party Balb / c cardiac allografts were transplanted in chimeric MRL mice to test for specificity.

An ardent devotee of rich ochres and earthy pigments, his painted tableaus are often foregrounded by chimeric creatures and humans, loosely bound to one another.

Yesterday, PTO granted a patent that claims gene inactivation by the use of chimeric restriction endonucleases to the Pasteur Institute and Boston Children's Hospital.

From the basic research perspective, the ability to generate chimeric histidine kinase molecules could allow the dissection of specific functions of the individual components in multigene families.

Anaplastic lymphoma kinase (ALK)-- positive anaplastic large cell lymphoma (ALCL) frequently carries the t (2; 5)(p23; q35) resulting in aberrant expression of chimeric nucleophosmin - ALK.

(D) Testes of the male chimeric mouse were sliced transversely and analyzed for EGFP and Oct4 expression.

In a similar way, we used HV lacZ ES cells to ask whether the V+S + fraction would preferentially segregate to the outside of chimeric EBs.

The subjects of his depictions are chimeric creatures in a state of metamorphosis; combinations of animals, organic forms, and natural elements inspired by the ecosystem of the place where the artist works.

Juno Therapeutics has halted development of JCAR015, its lead chimeric antigen receptor (CAR) T - cell cancer immunotherapy indicated for adults with relapsed / refractory B - cell acute lymphoblastic leukemia (ALL), nearly 4 months after placing a Phase II trial of the candidate on its second clinical hold following two additional patient deaths.

In their latest study, Potash and colleagues describe the efficient and reproducible transmission of chimeric HIV from infected male mice to uninfected females via mating, providing the first report of HIV transmission by coitus in an animal model.

The clinical hold pushes back Juno's earlier plans to pursue FDA approval next year for JCAR015, a CD19 - directed chimeric antigen receptor technology (CAR - T) product candidate that has been under study in ROCKET in adult patients with relapsed or refractory B - cell acute lymphoblastic leukemia.

The function of specific structural domains of these receptors was determined after construction and expression of a series of chimeric alpha 2 -, beta 2 - adrenergic receptor genes.

Through gene therapy, researchers engineered blood - forming stem cells (hematopoietic stem / progenitor cells, or HSPCs) to carry chimeric antigen receptor (CAR) genes to make cells that can detect and destroy HIV - infected cells.

Although it wasn't the first time chimeric pigs were created, it was the first time they came about using cloned pluripotent cells.

He and his student Allan Bradley and postdoctoral fellow Elizabeth Robertson had demonstrated that ES cells could generate chimeric animals capable of transmitting their genetic material to offspring.

Researchers fused part of a mouse - derived antibody to part of a human antibody (creating chimeric mAbs) and grafted even smaller bits of mouse antibodies into human antibodies (humanized mAbs).

The periplasmic portion of Trg has previously been fused to the cytoplasmic portion of a histidine kinase (HK), EnvZ, producing the functional chimeric protein Trz [8].

Top Ten Clinical Research Achievement Award Re-engineering Chimeric Antigen Receptor T Cells for Targeted Therapy of Autoimmunity

Installation view of ChimaTEK: Virtual Chimeric Space (detail), at Seattle Art Museum, 2015.

The world's first chimeric monkeys were created in a laboratory last year, and they offer surprising new insights into embryonic stem cell therapy: One reason for often - poor treatment outcomes may be that we're using embryos that are, strangely, just too old.

Bellicum is among the flurry of biotechs investing heavily into cell therapies such as experimental chimeric antigen receptor T - cell (CAR - T) treatments for cancer (this is the next - gen treatment that involves reprogramming immune cells to become cancer killers and has shown promise in blood cancers, which Bellicum specializes in).

Microchimerism is more common in patients suffering from Multiple Sclerosis than in their healthy siblings, suggesting chimeric cells may have a detrimental role in this disease, perhaps by setting off an autoimmune attack.

Researchers at The University of Texas MD Anderson Cancer Center developed a novel chimeric mouse model to test the combination therapy using immune checkpoint blockades with therapies targeting myeloid - derived suppressor cells (MDSCs).

The finding could fundamentally change how we look at human stem cell tech: If chimeric monkeys require totipotent cells before they can come into being, it stands to reason that human embryonic stem cell therapy might also require totipotent stem cells to render cures.

Here, we show that in the antibody - mediated autoimmune disease pemphigus vulgaris (PV), autoantigen - based chimeric immunoreceptors can direct T cells to kill autoreactive B lymphocytes through the specificity of the B cell receptor (BCR).

We took advantage of technology for chloroplast genome transformation to introduce chimeric minigenes expressing transcripts with altered or divergent cis - elements.

We have introduced chimeric genes which express GFP in a variety of organelles within the plant cell in order to study the dynamics of cell organization.

There has even been work on chimeric chickens in Scotland, Australia, and California.