Sentences with phrase «chimeric human»

Osteosarcoma: Evaluation of a Recombinant, Attenuated Listeria Monocytogenes Expressing a Chimeric Human Her2 / neu Protein (ADXS31 - 164c) in Dogs With Osteosarcoma in the Adjuvant Setting

Trianni has the leading chimeric human mouse for generation of fully human antibodies.

Extracts from the brains of FFI patients transmitted disease to transgenic mice expressing a chimeric human - mouse PrP gene about 200 days after inoculation and induced formation of the 19 - kilodalton PrPSc fragment, whereas extracts from the brains of familial and sporadic Creutzfeldt - Jakob disease patients produced the 21 - kilodalton PrPSc fragment in these mice.

Not exact matches

They found that hepatitis in these «human hepatocyte chimeric mice» was caused by white blood cells known as cytotoxic T lymphocytes (CTLs) that were specifically targeted to hepatitis B virus.

Hybrid, or chimeric, animals may eventually grow human organs to be used in transplants.

McCain would ban scientists from using donor eggs to create disease - specific stem cell lines or chimeric animals to see how human stem cells behave during development.

More recently, researchers have suggested that chimeric sheep could grow human organs for transplantation.

The finding could fundamentally change how we look at human stem cell tech: If chimeric monkeys require totipotent cells before they can come into being, it stands to reason that human embryonic stem cell therapy might also require totipotent stem cells to render cures.

Over the past two years, investigators from the Perelman School of Medicine at the University of Pennsylvania have reported results from a human trial in GBM using chimeric antigen receptor (CAR) T cell therapy, through which patients» own T cells were engineered to track down and kill cancer cells that express a tumor - specific protein known as EGFRvIII.

Some worry that such human cells, when combined with animal embryos, could develop into brain cells, sperm, or egg cells in the chimeric offspring.

Biologist Stuart Newman of the New York Medical College in Valhalla is trying to get a patent on a «humanzee» — a chimeric animal made from human and chimpanzee embryos.

North says his group has already generated a human chimeric form of MAG - 1 that is equally effective as mouse MAG - 1, and they are now generating a humanized form for use in patients.

Chimeric mice could also provide more clues about brain evolution by helping researchers identify astrocyte specializations that are unique to humans.

The work stems from an earlier collaboration between Potash and David J. Volsky (also from Columbia University); they established a chimeric HIV clone with a genetic modification that allows the virus to propagate in rodents instead of humans.

Fialuridine induces acute liver failure in chimeric TK - NOG mice: A model for detecting hepatic drug toxicity prior to human testing.

The same technique — injecting pluripotent stem cells into early embryos — failed with other combinations: The scientists couldn't create rat - pig chimeras, and although they produced human - cow chimeric embryos, they did not transfer them into cows to develop into fetuses.

The proposed gene therapy is based on the success of small human trials of killer T - cells (Chimeric Antigen Receptor [CAR] T - cell therapy).

The line 85 mice carry two transgenes, the mouse / human chimeric APP / Swe, linked to Swedish FAD and human PS1ΔE9.

Expression of Chimeric Receptor CD4zeta by Natural Killer Cells Derived from Human Pluripotent Stem Cells Improves In Vitro Activity but Does Not Enhance Suppression of HIV Infection In Vivo.

EXPERIMENTAL DESIGN: The chimeric (c) 11 - 1F4 mAb was produced in CHOdhfr - stable mammalian cell lines that had been transfected with a supervector DNA encoding the mouse 11 - 1F4 heavy and light chain variable regions (V (H), V (L)-RRB- and human heavy and light chain constant regions (C (H), C (L)-RRB-.

mesothelin - specific chimeric antigen receptor (CAR) were capable of ablating large human mesothelioma tumors when infused into mice.

Spontaneous expansion of the CAG repeat stretch in the CAG 140 KI mouse model, which carries a chimeric mouse / human exon 1 containing around 125 CAG repeats and the human polyproline region inserted in the murine huntingtin gene (Menalled et al., 2003, Hickey et al., 2008), has recently led to a new KI line that carries around 190 CAG repeats (CAG 190 KI) in a congenic C57Bl / 6J background.

The CAG 140 KI mouse model carries a chimeric mouse / human exon 1 containing around 125 CAG repeats and the human polyproline region inserted in the murine huntingtin gene.

These three artists share a penchant for the garish and provocative: through the use of bold colors and tantalizing aesthetics, their artworks portray disconcerting human stereotypes as well as chimeric monsters.

I keep mulling the concept «chimeric embryo» now that I've read Bill Heinze's post that the U.S. Patent and Trademark Office is examining what it means to be human.