EXPERIMENTAL DESIGN: The
chimeric (c) 11 - 1F4
mAb was produced in CHOdhfr - stable mammalian cell lines that had been transfected with a supervector DNA encoding the mouse 11 - 1F4 heavy and light chain variable regions (V (H), V (L)-RRB- and human heavy and light chain constant regions (C (H), C (L)-RRB-.