There is only about a 1.6 percent difference between
the chimpanzee genome and ours.
For more on the scientific rationale for sequencing the chimp genome, go to: Sequencing
the Chimpanzee Genome.
The chimpanzee genome differs from the bonobo genome by about 0.3 percent, which is one - fourth the distance between humans and chimps.
Initial sequence of
the chimpanzee genome and comparison with the human genome.
The researchers used the very large survey of human genetic variation called HapMap for their analysis, which compared human variations with
the chimpanzee genome.
Comparisons of the human genome and the newly completed draft of
the chimpanzee genome have unearthed major differences between the patterns of large duplicated segments of DNA in the two species...
Comparisons with
the chimpanzee genome indicate that human SIGLEC11 emerged through human - specific gene conversion by an adjacent pseudogene.
Then just four months ago, a team of researchers reported that they had likewise sequenced the complete
chimpanzee genome.
The genetic evidence shows that a little less than 1 per cent of
the chimpanzee genome came from bonobos, from one contact between 200,000 and 550,000 years ago and another, more recent one less than 200,000 years ago.
Pääbo will continue sequencing Neanderthal DNA until he has a genome that is similar in completion and quality to the existing map of
the chimpanzee genome.
When researchers sequenced
the chimpanzee genome in 2005, the biggest difference between it and the human genome was the extinct PtERV1 retrovirus, which inserted its DNA into the cells it infected like HIV does today.
As
the chimpanzee genome is roughly three - gigabases in length, the volume of this sequence data was unprecedented, enabling the scientists to decipher precise mutation trajectories occuring within one generation.
Additional support could come from
the chimpanzee genome, which may allow researchers to clock when the genes for slow - twitch muscle fibers — crucial for running long distances and plentiful in people but not chimps — diverged in the common evolutionary history of humans and apes.
This cover story is a look at what information has been coming out of direct genetic comparisons of
the chimpanzee genome and the human genome.
Now that scientists have decoded
the chimpanzee genome, we know that 98 percent of our DNA is the same.
Our genome is nearly identical to
the chimpanzee genome, a little less identical to the gorilla genome, a little less identical to the orangutan genome, and so on — and this correspondence is present in ways that are not needed for function (such as the location of shared genetic defects, the order of genes on chromosomes, and on and on).
Research comparing human and
chimpanzee genomes, published in Nature, found that there are more than 40 million differences between the two species» base pairs, which are the DNA building blocks.
Producing a short list of strong candidates was in itself a feat, accomplished by applying the right filters to analysis of human and
chimpanzee genomes, said co-author Gregory Wray, professor of biology and director of the Duke Center for Genomic and Computational Biology.
To find out why, David Haussler of the University of California at Santa Cruz compared the human and
chimpanzee genomes.
Hvilsom noted that their comprehensive analyses of
chimpanzee genomes revealed that the apes» genetic information can be used to determine from which country, and even which region, individual chimpanzees originated.
Although the human and
chimpanzee genomes are distinguished by 35 million differences in individual DNA «letters,» only about 50,000 of those differences alter the sequences of proteins.
Not exact matches
It could have been that
chimpanzees and human
genomes showed no evidence of having a common ancestor.
Indeed, it turned out that unlike the uniformly - paced evolution of the
genome, the metabolome of the human brain has evolved four times faster than that of the
chimpanzee.
Genome sequencing has confirmed to the satisfaction of pretty much everybody that this dubious honour goes to
chimpanzees.
Much of what sets us apart from our
chimpanzee relatives comes from bits of DNA that hop (or have hopped) around our
genomes.
By comparing it with that of modern humans,
chimpanzees and bonobos, plus Neanderthals and Denisovans, Meyer estimated its age at 400,000 years, twice as old as our own species and far older than any hominin
genome previously sequenced (Nature, DOI: 10.1038 / nature12788).
Boyd et al. sequenced the
genomes of symbiotic bacteria from human lice as well as the closely related
chimpanzee, gorilla and red colobus monkey lice.
Intriguingly, the new genetic resistance locus lies within a region of the
genome where humans and
chimpanzees have been known to share particular combinations of DNA variants, known as haplotypes.
In a companion paper published this week in
Genome Research, Sudmant and Eichler wrote that they inadvertently found the first genetic evidence in a
chimpanzee of a disorder resembling Smith - Magenis syndrome, a disabling physical, mental and behavioral condition in humans.
He says this idea has «very profound» implications for the debate over the origins of bacterial genes that are present in the human
genome but absent in our closest relatives (Science, 8 June, p. 1903): The amount of conjugation Waters detected is «high enough to readily explain» the possible infiltration of bacterial genesinto our DNA, meaning that conjugation could have happened quickly enough to add genes only to humans, in the years since they split from the common ancestor they shared with
chimpanzees.
The
genome of our closest living relative — the
chimpanzee — has been released by an international consortium of scientists.
They compared each site in the Neanderthal
genome to the corresponding site in the
genomes of humans, as well as the
genome of a
chimpanzee.
To gain more insights, Marques - Bonet and colleagues analyzed the complete
genomes of 10 bonobos and 65
chimpanzees.
Rewiring gene activity in humans happened, in part, when transposons inserted themselves into the
genomes of human ancestors after the split from
chimpanzees, he reported last year in
Genome Biology and Evolution.
When the Max Planck scientists compared the bonobo
genome directly with that of chimps and humans, however, they found that a small bit of our DNA, about 1.6 %, is shared with only the bonobo, but not
chimpanzees.
The analysis of Ulindi's complete
genome, reported online today in Nature, reveals that bonobos and
chimpanzees share 99.6 % of their DNA.
Ever since researchers sequenced the chimp
genome in 2005, they have known that humans share about 99 % of our DNA with
chimpanzees, making them our closest living relatives.
After analyzing human DNA from several populations around the world and examining primate
genomes dating back to the shared ancestor of both humans and
chimpanzees, researchers reached a striking conclusion that several gene variants linked to schizophrenia were actually positively selected and remained largely unchanged over time, suggesting that there was some advantage to having them.
Indeed, looking at
genomes of humans and
chimpanzees that had already been sequenced, the researchers found that the primates had more copies of L1 sequences than did humans.
The team found that ARHGAP11B was also present in Neanderthals and Denisovans, human cousins with similarly sized brains, but not in
chimpanzees, with which we share 99 percent of our
genome — further support for the idea that this gene could explain our unusually large human brains.
Comparing three million letters of the
chimpanzee genetic code with the human
genome draft, Svante Pbo of the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany, and his colleagues found only a 1.3 percent difference between the two.
Now, the view of the ancient
genome is so clear that Meyer and his colleagues were able to detect for the first time that Denisovans, like modern humans, had 23 pairs of chromosomes, rather than 24 pairs, as in
chimpanzees.
The
genomes of humans and our closest living relatives, the
chimpanzees, differ by just 1.23 percent.
It is known, however, that humans»
genomes are less variable than
chimpanzees».
Svante Pääbo Last year Pääbo announced a plan to sequence the entire Neanderthal
genome by 2008 and compare our extinct relative's genes with the genes of
chimpanzees and humans.
Based on the six other published mammalian
genomes (human,
chimpanzee, mouse, rat, dog and cow), the sequencers estimated that the feline
genome contained some 20,000 genes.
The effects of these deleterious mutations in humans and
chimpanzees are probably either inconsequential or else they are compensated by adaptive changes elsewhere in the
genome, Keightley says.
I'd like to see a re-doing of all the great ape
genomes, including
chimpanzee and orangutan, to get a comprehensive view of the genetic variants that distinguish humans from the great apes.
The sequencing of the human
genome (ScienceNOW, 14 April 2003:) gave scientists major new insights into what makes us human: Although we share more than 98 % of our genetic code with the
chimpanzee, natural selection has turned us into a very different animal than the chimps, from whom our hominid ancestors split evolutionarily some 6 million years ago (ScienceNOW, 31 August).
If you compare any two people from far - flung corners of the globe, their
genomes will be much more similar than those of any pair of
chimpanzees, gorillas, or other apes from different populations.