Researchers in the Doyle lab at Princeton have developed a direct and selective cross-coupling reaction that employs
a chiral nickel catalyst and an activating agent at low temperatures to couple nucleophilic arenes, common motifs in bioactive compounds, with a feedstock chemical known as pyridine.
Published in Chemical Science, the reaction employs
a chiral nickel catalyst and an activating agent at low temperatures to couple nucleophilic arenes, common motifs in bioactive compounds, with a feedstock chemical known as pyridine.