Despite the wide use
of chlorambucil in cats, the pharmacokinetic parameters (i.e. how the body absorbs, metabolizes and eliminates the drug) have not been previously studied in cats.
Purpose of Study: Small cell GI lymphoma is commonly diagnosed in older cats and recommended treatment of this cancer is an oral chemotherapy drug called
chlorambucil in combination with prednisolone or prednisone.
The gold standard of treatment is steroids and / or immunosuppressants - specifically a drug
called chlorambucil.
If you have any questions or concerns
about chlorambucil or the condition it was prescribed for, contact your veterinarian.
Rituximab plus bendamustine or
chlorambucil for chronic lymphocytic leukemia: primary analysis of the randomized, open - label MABLE study
If none of these medications successfully controls the symptoms of IBD, more potent immunosuppressive drugs, such
as chlorambucil or azathioprine, may be necessary.
In the last couple of years, it has been recognized that after long term treatment (many moths to a year or more) with
metronomic chlorambucil, that chronic suppression of the bone marrow can occur resulting in prolonged low platelet or white blood cell counts.
Briefly, in a study at Purdue University, a series of 31 dogs with TCC were treated with low dose
oral chlorambucil (also called leukeran).
Typically, oral chemotherapy drugs (
chlorambucil and prednisolone) are used.
Steroids and
chlorambucil can keep a cat with small cell lymphoma in remission for months.
Knowledge of the pharmacokinetic parameters of
chlorambucil in this population of older, cancer - bearing cats is critical to understand why some cats experience side effects with chlorambucil therapy and determine if variability in the metabolism of chlorambucil contributes to treatment failure.
Another protocol (UW - M) claims to have achieved the longest remission time using vincristine, L - asparaginase,
chlorambucil, methotrexate, and doxorubicin.
Drugs like cyclophosphamide, and
chlorambucil.
FIV positive cats), or those with chronic infections Fertility can be affected permanently in young pets If your pet has had an allergic reaction to
chlorambucil or like products Directions:
Low - grade lymphoma is treated with prednisone (a steroid) and
chlorambucil (an oral chemotherapy agent).
These include Interferon - alpha, lactoferrin, and
chlorambucil.
Drugs such as prednisone and azathioprine (Imuran Rx) have been used for this in dogs and
chlorambucil is sometimes helpful in cats.
Steroids have a high risk of diabetes with long term high dose administration, and
chlorambucil can cause anorexia and bone marrow suppression.
Treatment typically includes vitamin supplementation, prednisolone and
chlorambucil.
Other immunosuppressive medicines include azathioprine,
chlorambucil and budesonide.
e drugs involved include vincristine, cyclophosphamide, doxorubicin,
chlorambucil and prednisone.
Like EGC, corticosteroids, diet changes and, when required, immunosuppressive agents like cyclosporine or
chlorambucil are treatment choices.