Sentences with phrase «chloroquine in»

Disadvantages do not outweigh the benefits — the impact of this study on the use of chloroquine in anti-cancer treatment

This study forms a new rationale for the use of chloroquine in anti-cancer treatment.

Not exact matches

Chloroquine was replaced by sulphadoxine - pyrimethamine (SP), but resistance to SP subsequently emerged in western Cambodia and again spread to Africa.

«Although chloroquine didn't completely clear Zika from infected mice it did reduce the viral load, suggesting it could limit the neurological damage found in newborns infected by the virus.»

«In the 1950's, the Brazilian health agencies added chloroquine into cooking salt and distributed it to the population in endemic areas as an effective way of spreading the inexpensive anti-malarial drug as a prophylactic on a wide scalIn the 1950's, the Brazilian health agencies added chloroquine into cooking salt and distributed it to the population in endemic areas as an effective way of spreading the inexpensive anti-malarial drug as a prophylactic on a wide scalin endemic areas as an effective way of spreading the inexpensive anti-malarial drug as a prophylactic on a wide scale.

Former mainstay drugs (chloroquine and sulfadoxine — pyrimethamine) also experienced their first resistance challenges in western Cambodia before spreading to other parts of Asia and on to Africa, where the parasites killed millions.

Resistance to chloroquine surfaced here in the 1950s before sweeping through the wider Mekong region and then into India and Africa, causing millions of deaths.

To find out, the team genetically modified mice to block production of Nppb in TRPV1 neurons, then injected the skin on their shoulders with a range of itch - inducing compounds, including histamine, an inflammatory molecule involved in immune responses, and the malaria drug chloroquine.

This sheds new light on the therapeutic schedule for combination therapy with chloroquine, which could result in decreased toxicity.

In this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia AgostiniIn this study, we found that chloroquine not only has an effect on the growth of the cancer cells, but also makes the tumor environment less aggressive by normalizing the abnormal blood vessels in the tumor,» says Patrizia Agostiniin the tumor,» says Patrizia Agostinis.

Therefore, chloroquine can nip the metastatic spreading of cancer cells in the bud, which is the most important therapeutic goal in any tumor treatment.»

With a view to clinical studies (tests on humans) it is important to note that the effects on the tumor vasculature were even observed at chloroquine concentrations that had little effect on autophagy in the cancer cells.

However, a recent study by investigators at VIB and KU Leuven has demonstrated that chloroquine also normalizes the abnormal blood vessels in tumors.

«Although it is assumed that chloroquine strengthens anti-cancer treatment by blocking autophagy, there is little in vivo evidence that this is the only way in which chloroquine works.

And if it somehow did, Africa is much better equipped to deal with than it was in the 1980s when chloroquine resistance hit, WHO experts say, with strong national malaria programs in place and increased monitoring of drug efficacy.

Chloroquine was used in the late 1940s to early 1950s, until the malaria parasite grew resistant while Amodiaquine is still being used in Africa today.

Even in chloroquine's heyday, the drug's demise loomed.

The professor and his colleagues demonstrated in their study that while resistance to drugs like chloroquine, which works to slow the growth of malaria, has been explored, an explanation of the resistance to the cell - destroying effects of the medication has not been fully understood.

Within 20 years, mass chloroquine treatment, along with DDT spraying and other antimosquito measures, removed the threat of disease from more than 500 million people living in formerly malaria - ridden areas.

In these experiments, the botanical tea performed as well as chloroquine and quinine.

I recently recalled that little girl and countless other children saved from certain death by chloroquine because I was reading about 80 U.S. Marines struck with falciparum malaria a few weeks after deploying to Liberia in August 2003.

Meanwhile, back in Asia, chloroquine resistance was hardly invisible to the U.S. military.

On top of that, chloroquine does not take effect in the liver — so it is unable to prevent the parasite from reproducing.

In tomorrow's issue of The New England Journal of Medicine, researchers report the case of a woman who overdosed on chloroquine, a drug commonly used to fight the malaria parasite.

The researchers say such «hypopigmentation» occurs because chloroquine poisons pigment - producing cells in hair follicles.

Wellems's team was studying chromosome 7 of P. falciparum in search of a gene that renders malaria resistant to the drug chloroquine, when they came across a cluster of five related genetic sequences.

Despite these interventions 20 more introduced cases were reported in 2012 and, due to fears that the malaria parasite may be re-establishing in the area, a program of mass drug administration of one course of chloroquine and primaquine, which are the first line recommended antimalarials for P. vivax.

«By targeting a single channel in the periphery, it may be possible to reduce histamine - induced itching, chloroquine - induced itching and even types of chronic itching that don't respond to current therapies.»

And they also learned that TRPV1, the channel that transmits histamine - induced itch, also plays a role in chloroquine - induced itch by helping TRPV4 process itch signals.

In the early 2000s, the malaria parasite Plasmodium falciparum developed resistance to the commonly used antimalarial drug chloroquine.

Using chloroquine, the researchers not only increased the circulation of nanoparticles in the body, but also reduced the body's filtration of nanoparticles, as well as improved drug delivery to breast tumors.

Chloroquine was invented in the 1940s for the prevention and treatment of malaria.

He says that a combination of azithromycin and chloroquine (a common malaria drug), currently approved to treat pregnant women in areas at high risk of malaria, would be fairly easy to test in an initial human trial.

This work reinforces a previous study, published in Nature Scientific Reports last November, that shows the anti-malaria drug chloroquine reduces Zika transmission between mothers and babies in a mouse model.

«Chloroquine has been tested in pregnant women for the past 50 years in high doses and has been found safe,» says Terskikh.

Warhurst DC, Steele JC, Adagu IS, Craig JC, Cullander C. Hydroxychloroquine is much less active than chloroquine against chloroquine - resistant Plasmodium falciparum, in agreement with its physicochemical properties.

Project 523 was a secret military program initiated by the Chinese leadership in 1967 in supporting Vietnam government for searching medicines to treat anti chloroquine - resistant malaria.

The compound we've identified already appears to have better anti-malarial activity than Chloroquine, a standard drug on the market,» said David G.I. Kingston, a University Distinguished Professor of chemistry in the College of Science, researcher affiliated with the Fralin Life Science Institute, and director of the Virginia Tech Center for Drug Discovery.

It also provides an important insight into why antimalarial drug resistance (previously to chloroquine and antifols, and now to artemisinin) arises in Western Cambodia,» says Professor Nicholas White of Mahidol University in Bangkok, Thailand and Oxford University.

Remarkably, investigators at the Radboud University Nijmegen Medical Centre (RUNMC) in The Netherlands have shown that long - term sterile immunity (at least 28 months) to experimental P. falciparum - infection can be induced by exposing malaria - naïve volunteers to the bites of 15 P. falciparum - infected mosquitoes monthly for three months while on chloroquine prophylaxis (CPS immunization).

Chloroquine Prevention Of Murine MHC Disparate Acute Graft - Versus - Host Disease Correlates With Inhibition Of Spleenic Response To CpG Oligodeoxynucleotides And Alterations In T Cell Cytokine Production, Biol Blood Marrow Transplant 8 (12): 648 - 55, 2002.

Conclusions: The predominance of the Pf pfcrt CVIET and Pf dhfr IRN triple mutant parasites and absence of pfkelch13 resistance alleles suggest that the amodiaquine and pyrimethamine components of AS - AQ and SP may no longer be effective in their role while chloroquine resistance still persists in southwestern Cameroon.

In preclinical trials, the effect of chloroquine and hydroxychloroquine on tumorigenesis has been extensively investigated in mouse cancer models, including genetic and xenograft models (summarized in Table 2In preclinical trials, the effect of chloroquine and hydroxychloroquine on tumorigenesis has been extensively investigated in mouse cancer models, including genetic and xenograft models (summarized in Table 2in mouse cancer models, including genetic and xenograft models (summarized in Table 2in Table 2).