Nor are negative water tests conclusive:
cholera researchers say the bacteria are hard to find in fast - flowing rivers.
The genome data give
both cholera researchers and microbial ecologists a new way to look at the microbe.
Not exact matches
Researchers could now see the culprits and distinguish between similar diseases such as anthrax,
cholera and, yes, bubonic plague, which was isolated in 1894 and named Yersinia pestis in honor of Swiss microbiologist Alexandre Yersin.
Researchers have also found that ENSO patterns can be used to forecast
cholera outbreaks 11 months in advance in Bangladesh's capital.
But the Dutch
researchers suggest that other new
cholera epidemics may crop up in future.
They feared a new
cholera pandemic, and
researchers around the world scrambled to find the source of this dangerous new pathogen.
DNA from ancient microbes could also help today's medical
researchers keep one step ahead of fast - evolving diseases like
cholera and influenza.
The
researchers gathered DNA from a
cholera victim's intestines, which in 1849 were preserved in jars in the Mütter Museum in Philadelphia.
Dutch
researchers say the new strain arose when the bacterium that usually causes
cholera borrowed genes from a normally harmless strain.
This allowed the
researchers to uncover that different strains of Vibrio
cholerae can be assigned different risks for causing large outbreaks.
«As long as there are sufficient nucleic acids preserved in the specimen, there is really no limit,» says Alison Devault, a
researcher at McMaster University studying ancient
cholera.
One study in the Journal conducted by
researchers at the CDC finds that even relatively modest improvements — such as providing more latrines and community water pipes and disinfecting water with chlorine — could over the next two decades prevent up to 78,567 cases of
cholera.
Researchers from the Cochrane Infectious Diseases Group, co-ordinated through the editorial base in LSTM, conducted an independent review of the effects of treating
cholera with antimicrobial drugs, published in The Cochrane Library today.
From
cholera to bird flu,
researchers are studying how diseases spread at such events, in the hopes of preventing a future pandemic.
WASHINGTON, D.C. —
Researchers have unraveled the genetic code of Vibrio
cholerae, one of nature's most versatile microbes.
Another
researcher, Richard A. Finkelstein, said that participation in American Society of Microbiology (ASM) meetings supported his efforts to isolate and sequence toxins that cause
cholera, a deadly intestinal disease.
Forty years ago Levine was one of a tiny cadre of
researchers doing so - called human challenge studies — intentionally infecting people with V.
cholerae and other pathogens to test drugs and vaccines.
Princeton University
researchers have identified the protein that allows Vibrio
cholerae — the bacteria behind the life - threatening disease
cholera — to morph into a corkscrew shape that allows them to more effectively penetrate their victims» intestines.
Significantly, Salama said, the
researchers found that CrvA localizes to the periplasm, a cellular compartment between the outer and inner membrane of Gram - negative bacteria such as V.
cholerae.
In the image above, red - stained V.
cholerae bacteria (right) exhibit the shape - changing protein (stained green), which the
researchers named CrvA.
In experiments, the
researchers found that curved V.
cholerae cells could more easily move through a thick gel.
Normally, within the llama, these antibodies would adapt to a new antigen (via a process called somatic hypermutation), but the
researchers could not inject the animals with
cholera and wait for them to create the correct antibodies.
Given similar results from studies of a different oral
cholera vaccine in Asia, the
researchers argue that «additional evaluation of the optimal dosing schedule for oral
cholera vaccines with the goal of improving long - term immunity is warranted.»
The
researchers discovered the protein that allows the bacterium Vibrio
cholerae to morph into a corkscrew shape that likely helps it twist into — and then escape — the protective mucus that lines the inside of the gut.
To their surprise, the model that worked best predicted that
cholera survivors were only immune to the disease for a few months rather than for a few years, as
researchers previously believed.
The
researchers have demonstrated that in test tubes a particular chemical, called CAI - 1, can induce deadly
cholera cells to turn off their virulence genes.
Researchers from across the world have studied
cholera outbreaks in Africa, Latin America and the Caribbean from the last 60 years