The results of two studies, published in Science (10 November), present a new «rule - book» to estimate the risk of different
cholera strains causing an epidemic.
The results of two studies, published in Science, present a new «rule - book» to estimate the risk of different
cholera strains causing an epidemic.
Recent genomic advances are contributing to our understanding of the emergence and spread of a multidrug - resistant
cholera strain [78], for example, and helping to identify variants that might account for differences in host susceptibility to other waterborne infections such as schistosomiasis [79], [80].
Not exact matches
The symptoms and treatment of
cholera caused by the new
strain (designated V.
cholerae O139) are largely the same as for «normal»
cholera.
This is because while many adults in areas where there have been V.
cholerae O1 epidemics have developed some immunity to this
strain, they lack immunity to the new O139 vibrio.
Some came from Nepal, where
cholera is endemic, and although they showed no symptoms of
cholera, genetic fingerprinting has matched the
strain of
cholera in Haiti to the
strain prevalent in Southeast Asia.
Genetically, the Haiti
strain is very similar to South Asian
strains of V.
cholerae.
While the new discovery confirms scientists» ideas about the evolution of disease, the worrying implication is that the same process could cause other virulent
strains of
cholera to emerge at any time.
Although the
cholera bacterium, Vibrio
cholerae, is usually thought of as a disease - causing organism, most
strains never infect people and live freely in estuaries and other brackish waters.
So when a large number of
cholera cases caused by a new
strain named O139 started turning up in India, WHO officials were understandably alarmed.
So people who have built up immunity to
cholera could not fight off the new
strain because their immune systems were fooled into ignoring the bacterium.
Mooi and his colleagues have looked at the DNA of free - living V.
cholerae, and found that the different
strains seem to have exchanged genes on a fairly regular basis.
Dutch researchers say the new
strain arose when the bacterium that usually causes
cholera borrowed genes from a normally harmless
strain.
In Latin America, the team not only focused on the 7PET
strains that cause epidemics, but other
strains of Vibrio
cholerae that cause sporadic low level disease.
This allowed the researchers to uncover that different
strains of Vibrio
cholerae can be assigned different risks for causing large outbreaks.
Epidemiological and DNA studies have shown that the outbreak was caused by the «El Tor»
strain of Vibrio
cholerae bacteria probably carried by Nepalese peacekeepers.
But Rita Colwell of Johns Hopkins University in Baltimore, Maryland, and colleagues report this week that of faecal samples taken from 81 people in November 2010, 17 had a different V.
cholerae that does not make the deadly toxin made by the El Tor
strain.
Better sanitation is imperative in the fight against
cholera in Haiti & ndash particularly as a
strain impervious to proposed vaccinations has been found
What is more, the DNA in Haiti's
cholera shows it was a single, recent introduction of a
strain from south Asia, though we don't know if it is circulating in Nepal.
Around a decade later an unknown ship, probably from the Bay of Bengal, discharged ballast water into the coastal waters of Peru, releasing a
strain of
cholera that contaminated shellfish.
Among the arrivals they looked at were two
strains of the bacterium that causes human
cholera, Vibrio
cholerae O1 and O139.
Although no cases of
cholera were reported in Alabama, ballast - water samples collected later contained the epidemic - causing
strain of
cholera, and this incident highlighted the capability of ballast water to transport pathogens.
Circumstantial evidence suggests that a previously unreported
strain of
cholera found in oysters and fish - gut contents in Mobile Bay, Alabama during 1991, was transported there by ballast water from ships that arrived from Latin America, which had an ongoing
cholera epidemic.
Conclusions: We conclude that genetically related V.
cholerae cluster in outbreaks, and distinct
strains circulate simultaneously.
V.
cholerae successfully persist in aquatic environment and its pathogenic
strains results in sever enteric disease in humans.
The current, seventh
cholera pandemic (marked by a new
strain of the bacteria) began in Asia in 1961 and has since spread to Africa and the Americas.
Recently, the Centers for Disease Control and Prevention (CDC) published a travel notice warning travelers of an epidemic
strain of
cholera in Haiti.