The first level of contact with live cholera bacteria — or their dead counterparts contained in oral
cholera vaccines — occurs in the mucosa of the gut.
To prevent and control them, three oral
cholera vaccines are currently approved by WHO.
Two years later, at the request of NIAID's Cholera Panel, Levine's group added challenges with V. cholerae to test
cholera vaccines.
The finding has implications for
cholera vaccines.
The Federal Government, yesterday, deployed oral
cholera vaccines to be administered under the supervision of the Nigeria Centre for Disease Control (NCDC).
If you have ever consumed Shreddies or Oysterettes, Old Forester or Early Times, if you have used aureomycin hog
cholera vaccine, or if you have ever bought a water - jet massager for your gums, you have been under the influence of Loewy / Snaith.
Widespread community acceptance was evident and we are proud that while many other states clamoured for
cholera vaccine, our communities were effectively educated to the use and effectiveness of ORS in diarrhoea.
The move to drop the campaign reverses a difficult decision taken last month by the International Coordinating Group on Vaccine Provision, which agreed to ship out about half of its total supply of
cholera vaccine to the war - torn country.
But I also recognize that they are only able to secure a very small supply of vaccine and there are many competing priorities,» says Andrew Azman, an epidemiologist at Johns Hopkins Bloomberg School of Public Health in Baltimore, Maryland, who in the last month has been part of a team advising WHO on how to allocate
the cholera vaccine in Yemen.
But for now, Waldor, Clemens and Hotez, writing in The New England Journal of Medicine are calling for a global stockpile of
cholera vaccine so there will be enough for emergencies such as Haiti.
Two years after the earthquake and thousands of deaths later, the debate about whether to use
the cholera vaccine in Haiti continues
The special cholera section of the Journal also includes evidence that
cholera vaccine has a role to play in fighting the epidemic, despite the many challenges to achieving meaningful coverage in Haiti.
The study notes that by adding the oral
cholera vaccine (OCV) to the picture — and achieving a 20 percent coverage rate within five years — the number of cases averted could rise to 88,974.
They note that supply concerns are being addressed by a global effort to stockpile 2 million doses of
cholera vaccine.
The cholera studies led to the scuttling of a leading vaccine candidate, a finer understanding of effective immune responses, and, ultimately, compelling evidence that a different
cholera vaccine worked.
Jason Harris, from Massachusetts General Hospital in Boston, USA, and colleagues are studying a bivalent whole cell oral (BivWC)
cholera vaccine produced in India that received pre-approval by WHO in 2011.
Given similar results from studies of a different oral
cholera vaccine in Asia, the researchers argue that «additional evaluation of the optimal dosing schedule for oral cholera vaccines with the goal of improving long - term immunity is warranted.»
Stockpiles of cholera and yellow fever vaccine are limited, but a new
cholera vaccine manufacturer may help ease the shortage.
Intestinal worms may explain why a promising oral
cholera vaccine didn't work very well in the field
Sida's results are also achieved in other programmes worldwide: its support has been essential in the production of the Dukoral oral
cholera vaccine, which helps prevent cholera in adults and children and travellers» diarrhoea caused by bacteria from the E. coli family.
Not exact matches
The company also has
vaccines in clinical development for
cholera (Vaxchora), anthrax, HIV and hepatitis A.
The same
vaccine for
cholera is also effective against ETEC, and certain
vaccines are available for children as young as two.
Even though WHO advises that vaccination against «normal»
cholera is ineffective, some countries still promote the
vaccine.
Cholera vaccines have had limited success: in 2000, a promising
vaccine made from live, weakened
cholera bacteria protected 80 per cent of the North American or European adults who took it, but a much smaller proportion of Indonesians, with protection levels especially low in children.
This is because of a
vaccine stockpile set up in response to the
cholera that struck Haiti after an earthquake in 2010 —
cholera carried there, ironically, by Nepalese peacekeepers.
Another appears to work in one dose, rather than the usual two, so could protect people fast enough to slow a
cholera epidemic in mid-outbreak, says John Clemens of the International
Vaccine Institute in Seoul, South Korea.
But in a
cholera outbreak, many catch and spread the bacteria without getting sick, making it hard to tell who will still benefit from
vaccine.
A
cholera outbreak is a high probability in Nepal now, says Anuj Bhattachan of the International
Vaccine Institute in Seoul, who is in Nepal.
There are three
vaccines, all oral and made of dead
cholera bacteria.
People in regions in which
cholera is prevalent, such as Africa, do not use much
vaccine as the immunity the
vaccines elicit does not last long.
But Nepal also now has 18,000 doses of Shanchol, an oral
vaccine made of dead
cholera bacteria by Shantha Biotechnics of Hyderabad, India.
«Modelling the effect of
vaccines on
cholera transmission.»
«
Vaccines should not be viewed as a silver bullet that can subdue
cholera in Haiti but wider use of them, such as in campaigns targeting particularly vulnerable populations, can play a meaningful role in protecting people from illness and death.»
An analysis of vaccination policy by officials from PAHO and the Sabin
Vaccine Institute agrees that
cholera vaccination can be one component of an elimination plan.
Cholera vaccines now being tested will also not work on the new form, says Jim Tulloch, head of
cholera control at the WHO.
Forty years ago Levine was one of a tiny cadre of researchers doing so - called human challenge studies — intentionally infecting people with V.
cholerae and other pathogens to test drugs and
vaccines.
A study published in PLOS NTDs examining the immune response to one of them in Haitian adults finds that while the first
vaccine round elicits a strong
cholera - specific response in the mucosa (the first point of contact with the
cholera pathogen), the booster dose after 2 weeks does not appear to stimulate the immune system further.
They delivered preventive health services including
vaccines for rabies, Newcastle Disease, hog
cholera and anthrax.