Sentences with phrase «cholesterol lowering trials»
On November 1, 2016, the entire SPIRE clinical trials program was stopped when the sponsor, Pfizer, who manufactures bococizumab, discontinued the development of the drug when initial results from the LDL cholesterol lowering trials indicated that some trial participants had developed anti-drug antibodies, an immunologic response to the drug.
https://www.sciencedaily.com/ Not exact matches
Sanitarium conducted a clinical trial involving Australian adults with high cholesterol in 2016 with University of South Australia researchers to confirm the cholesterol lowering effects of the cereal.
The human trials are limited — as is often the case with food research — but the anecdotal evidence of chia's positive health effects include boosting energy, stabilizing blood sugar, aiding digestion, and lowering cholesterol.
• Non-GMO • Can help with satiety • Gluten - free • Consistent and adequate supply • Vegan / vegetarian • Intermediate - rate absorption • Low sodium • Ease of digestibility at all ages • Naturally cholesterol - free • Bland to sweet taste profile • Oryzatein is the only rice protein with 3rd - party clinical trials which shows it acts like a complete protein.
Six lipid - lowering trials randomized 4,449 patients, who previously had a heart attack or stroke or had extremely high baseline cholesterol levels and were on statin therapy, to receive either bococizumab (150 mg subcutaneously every 2 weeks) or placebo to determine the effects on LDL levels.
Inclisiran lowers low - density lipoprotein (LDL; «bad») cholesterol for up to one year in patients with high cardiovascular risk and elevated LDL cholesterol, according to late - breaking results from the ORION 1 trial presented today in a Hot Line LBCT Session at ESC Congress.
In a response to the Lancet review published in March, he and colleagues noted that the average cholesterol reductions actually achieved among lower risk groups in the trials were far below the 77 points that formed the basis for the conclusions.
The trial of research on ANGPTL3 as a potential target for atherosclerosis prevention began over a decade ago when scientists reported on two cases of familial hypolipidemia, a rare inherited condition involving abnormally low blood levels of cholesterol and triglycerides.
A statin drug commonly used to lower cholesterol is not effective in reducing the number and severity of flare ups from chronic obstructive pulmonary disease (COPD), according to the results of a large multicenter clinical trial designed and directed by Gerard J. Criner, MD, Director of Pulmonary and Critical Care Medicine at Temple University Hospital in Philadelphia, PA..
We get heavily hyped drugs like Avastin, which shrank tumors without adding significant time to cancer patients» lives (and increased the incidence of heart failure and blood clots to boot); Avandia, which lowered blood sugar in diabetics but raised the average risk of heart attack by 43 percent; torcetrapib, which raised both good cholesterol and death rates; and Flurizan, which reduced brain plaque but failed to slow the cognitive ravages of Alzheimer's disease before trials were finally halted in 2008.
It was also the first drug to prove that lowering cholesterol could prevent recurrent heart attacks compared to a placebo in a randomized clinical outcomes trial.
Despite lowering low - density lipoprotein (LDL), known as «bad» cholesterol, while markedly increasing levels of high - density lipoprotein (HDL), or «good» cholesterol, a large clinical trial to investigate the cholesterol drug evacetrapib was discontinued early after a preliminary analysis showed it did not reduce rates of major adverse cardiovascular events, according to research presented at the American College of Cardiology's 65th Annual Scientific Session.
All patients also received standard medical therapy throughout the trial, which in a vast majority of cases included treatment with statins or other cholesterol - lowering drugs.
Dr Nakano said: «Many randomised clinical trials, such as Treating to New Targets (TNT) and PROVE IT - TIMI, have shown that aggressive cholesterol lowering with statins improves clinical outcomes in patients with CAD and high LDL - C levels.1, 2 But until now it was not known whether aggressive lipid lowering with statins would also benefit CAD patients with very low LDL - C levels.»
Carefully analyzing studies and trials from 1957 to the present, investigators found that the whole diet approach, and specifically Mediterranean - style diets, are effective in preventing heart disease, even though they may not lower total serum or LDL cholesterol.
Researchers at Massachusetts Eye and Ear / Harvard Medical School and the University of Crete have conducted a phase I / II clinical trial investigating the efficacy of statins (cholesterol - lowering medications) for the treatment of patients with the dry form of age - related macular degeneration (AMD)-- the leading cause of blindness in the developed world.
Originally developed to lower cholesterol levels, statins have also been investigated as potential anti-cancer drugs, but clinical trials have so far produced mixed results.
ABI indicates ankle - brachial index; ALT, alanine transaminase; ASCVD, atherosclerotic cardiovascular disease; CAC, coronary artery calcium; CK, creatine kinase; FH, familial hypercholesterolemia; LDL - C, low - density lipoprotein cholesterol; MI, myocardial infarction; RCT, randomized controlled trial; and ULN, upper limit of normal.
• Because few trials have been performed with nonstatin cholesterol - lowering drugs in the statin era, and those that have been performed were unable to demonstrate significant additional ASCVD event reductions in the RCT populations studied, there was less evidence to support the use of nonstatin drugs for ASCVD prevention.
ABI indicates ankle - brachial index; ASCVD, atherosclerotic cardiovascular disease; CAC, coronary artery calcium; hs - CRP, high - sensitivity C - reactive protein; LDL - C, low - density lipoprotein cholesterol; MI, myocardial infarction; and RCT, randomized controlled trial.
In March 2008, a 15,000 - person study comparing Crestor (rosuvastatin) against placebo in two groups of outwardly healthy people with low levels of LDL cholesterol and high levels of CRP was stopped early — a «stunning» outcome, the lead researcher said at the time — because the reduction in cardiac events was so marked among the participants taking the drug that to continue the trial and deprive the placebo group of the drugs benefits would have been unethical.
Over that time period, 347 heart drugs entered clinical trials, most of them to treat high blood pressure, prevent clotting and lower lipid levels (such as cholesterol) in the blood.
«Based on currently available data, patients should not stop taking Vytorin or other cholesterol - lowering drugs and should talk to their doctor or other health - care professional if they have any questions about Vytorin, Zetia, or the ENHANCE trial.»
And although more clinical trials about the benefits of curcumin for humans are needed, it's been linked to lower total cholesterol levels and improved liver function after liver disease or damage.
For example, a meta - analysis of 17 low - carb diet trials covering 1,140 obese patients published in the journal Obesity Reviews found that low - carb diets neither increased nor decreased LDL «bad» cholesterol.
«This systematic review and meta - regression analysis of 108 randomised controlled trials using lipid modifying interventions did not show an association between treatment mediated change in high density lipoprotein cholesterol and risk ratios for coronary heart disease events, coronary heart disease deaths, or total deaths whenever change in low density lipoprotein cholesterol was taken into account.
In several clinical trials of interventions designed to lower plasma cholesterol, reductions in coronary heart disease mortality have been offset by an unexplained rise in suicides and other violent deaths
The first clinical trial, which was conducted in China, tested the ability of red yeast rice to lower cholesterol in people who did not follow low - cholesterol diets.
In clinical trials lasting from 6 to 50 weeks, in individuals with increased blood cholesterol levels, guar gum (15 - 30 g / day) has lowered the total and LDL cholesterol for up to 20 % (but did not affect triglycerides and HDL cholesterol)[1,7,10,11,12,13,18].
In fact, Morgan, Palinkas, Barrett - Connor, and Winged (1993) articulate this with, «In several clinical trials of interventions designed to lower plasma cholesterol, reductions in coronary heart disease mortality have been offset by an unexplained rise in suicides and other violent deaths» (p. 75).
«Available evidence from randomized controlled trials shows that replacement of saturated fat in the diet with linoleic acid [vegetable oil] effectively lowers serum cholesterol but does not support the hypothesis that this translates to a lower risk of death from coronary heart disease or all causes.
That trial — somewhat unusual in that it was conducted before Pfizer sought F.D.A. approval — also showed that torcetrapib lowered LDL cholesterol while raising HDL, or good cholesterol.
Clinical trials have shown nuts help lower cholesterol and oxidation, and improve our arterial function and blood sugar levels.
... Longer - term clinical trials and careful postmarketing surveillance during the next several decades are needed to determine whether cholesterol - lowering drugs cause cancer in humans.
Several clinical trials have reported that diets that incorporate avocado may help lower levels of L.D.L., or «bad,» cholesterol, because the fruit contains plant sterols called phytosterols that compete with cholesterol for absorption in the intestines.
In a 2016 review published in The Journal of Nutrition, the author assessed 20 different trials on humans, and concluded that garlic supplements successfully lowered blood pressure and improved elevated cholesterol levels — both of which are risk factors for heart disease.
Furthermore, several clinical trials have found that vegetarian diets, also known to lower serum cholesterol have favorable effects on measures of mood and stress.»
I don't think we know for sure, but here is a quote from Healthy Longevity: «In regards to depressive symptoms, a recent review of clinical trials found that cholesterol lowering statins are associated with improvements in mood scores.
The results from this trial clearly indicate that the replacement of refined carbohydrates with EPRO and UFA increased insulin sensitivity, LDL peak particle size, and lowered fasting TG and VLDL cholesterol concentrations in men and women with an elevated TG concentrations.
Many publications have shown that garlic supports the cardiovascular system, while earlier trials suggest it may lower cholesterol and triglyceride levels in the blood.
In contrast, large reviews of previous trials suggest that very LC diets may have less favorable effects on LDL cholesterol than conventional high - carb, low - fat diets (13, 14).
In fact, in a randomized, double - blind, placebo - controlled clinical trial of hyperlipidemic patients, cucumber administered daily for six weeks significantly reduced total cholesterol, triglycerides (TG), and low - density lipoprotein cholesterol (LDL - C), while increasing levels of high - density lipoprotein (HDL - C)(Soltani et al., 2016).
They then conducted what went down in history as the Coronary Primary Prevention Trial, successfully lowering the risk of heart disease using cholestyramine, a drug that increases the conversion of cholesterol to bile acids.
TRUTH: In the two most recent trials, involving over 10,000 subjects, cholesterol - lowering did not result in any improvement in outcome.
There are short term trials demonstrating cholesterol lowering, but there hasn't been longer - term hard endpoint trial that would achieve similar attention that other vegetable oils like canola have achieved.
Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S).
Follow - up reports from the DASH trial showed that in addition to improving blood pressure, the DASH diet also lowered LDL cholesterol levels.
Three NHLBI - funded trials showed the health benefits of the DASH diet, such as lowering high blood pressure and LDL (bad) cholesterol in the blood, and shaped the final DASH eating plan recommendations.
-- In another trial with diabetic patients published in the European Journal of Clinical Nutrition in 1990, those who consumed powdered fenugreek had significantly lower blood levels of both glucose and cholesterol compared to others who took a placebo.
In addition, viscous Functional Fibers such as guar, pectin, and psyllium, have been tested in intervention trials and found to decrease serum total and low density lipo - protein (LDL) cholesterol concentration in most studies.