This involves moving
cholesterol out of the cell via a membrane protein called ABCA1 and assembling this cholesterol onto apoAI to form HDL.
To that end, she genetically engineered mice to lack a protein that transports
cholesterol out of cells in order to analyze experimentally what happens when immune cells remain abnormally packed with cholesterol.
Not exact matches
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«We would take foam
cell [models] and make them chock full
of cholesterol, put HDL outside the
cell, and see how well
cholesterol was moving
out of the
cell — the more HDL the better,» Rodriguez recalls.
Enrich points
out that «in the
cell,
cholesterol controls the trafficking
of vesicles, which are responsible for transporting integrins to
cell surface.
If this is anything like the dynamics going on, then only when
cholesterol levels drop below the saturation level will it move
out of the foam
cells and into the blood.
To me it seem like plaques form when the blood becomes «saturated» with
cholesterol and it «precipitates»
out in the walls
of the arteries where it is eaten by immune
cells which turn into foam
cells when they become engorged with
cholesterol.
The
cell considers this a threat to its health and increases the thickness
of the
cell walls - with
cholesterol - to keep the inside fluids from leaking
out.
For more on the topic, check
out these videos:
Cholesterol Feeds Breast Cancer
Cells The Actual Benefit
of Diet vs. Drugs Does
Cholesterol Size Matter?
These plaques start
out as minor injuries to the inner lining
of the arteries, which allow lipids (apo - B lipids mainly found in LDL
cholesterol) to enter those
cells.
Coconut really throws the whole «marker» issue
out of whack because it increases the energy state
of the
cell, which increases
cholesterol synthesis.»
Cholesterol helps to build and maintain
cell membranes, determines what substances can pass in and
out of the
cells, is important for the metabolism
of fat - soluble vitamins, insulates nerve fibers, and most importantly is involved in the production
of sex hormones, including testosterone.
And so if you're taking a cancer
cell and trying to cut it off from being able to burn sugar, basically this wabane is made
out of cholesterol.