Osmotic release of β - glucuronidase from polymorphonuclear leukocyte lysosomes is inhibited by catecholamines and adenosine 3», 5» - monophosphate, and accelerated by cholinergic agents and guanosine 3», 5» - monophosphate.
All of the nerve agents, old and new, operate on the same biochemical principles and cause the same mechanism of injury by provoking a «cholinergic crisis».