Sentences with phrase «cholinergic neurons»

Choline also helps form certain cholinergic neurons associated with mood, memory, and muscle control.

In another case, the mice had fewer cholinergic neurons.

memory; Alzheimer's disease; epilepsy; schizophrénia; cholinergic neurons; AMPA receptor; NMDA receptor; anterior congulate cortex; hippocampus

They also show altered noradrenergic transmission in the hippocampus and cerebral cortex and degeneration of basal forebrain cholinergic neurons by 6 months of age.

Cholinergic neurons are among the first to be lost in AD [86, 87] and acetylcholine is the therapeutic target for most FDA approved drugs for AD [88, 89].

C. Van Dort et al. «Optogenetic activation of cholinergic neurons in the PPT or LDT induces REM sleep.»

As a graduate student in James Townsel's lab, he studied the regulation and function of choline receptors, which are responsible for the transport of cholinergic neurons.

In the study, scientists examined basal forebrain cholinergic neurons to try to understand why they are damaged early and are among the first to die in normal aging and in Alzheimer's.

To test that, the authors reduced dati expression in different tissues using a technology called RNA interference (RNAi) and found it to be required in the nervous system, in cholinergic neurons.

Dr Elson said: «This is the only study to date to characterise mitochondrial DNA errors in cholinergic neurons, a neuronal population that is highly vulnerable to cell death in Parkinson's disease patients.

«With this work, we are beginning to understand the role that changes in mitochondrial DNA play in the death of cholinergic neurons, which has been shown to be pivotal in the onset and progression of motor and non-motor Parkinson's disease symptoms.»

This study showed that mtDNA levels are higher in the surviving cholinergic neurons of the brainstem, but with both cell - types that undergo profound degeneration during Parkinson's disease.

Identifying changes in the mitochondrial DNA in PPN cholinergic neurons has the potential to allow the development of more effective treatments targeted to specific cell - types.

The team then investigated whether the chemical might be inducing sleep by acting on the cholinergic neurons in the basal forebrain.

Classical hallmarks of Alzheimer's disease (AD) are a synaptic loss, cholinergic neuron death, and abnormal protein deposition, particularly of toxic amyloid - β peptide (Aβ) that is derived from amyloid - β protein precursor (AβPP) by the action of beta - and gamma - secretases.

Abstract: Classical hallmarks of Alzheimer's disease (AD) are a synaptic loss, cholinergic neuron death, and abnormal protein deposition, particularly of toxic amyloid - β peptide (Aβ) that is derived from amyloid - β protein precursor (AβPP) by the action of beta - and gamma - secretases.

Percentage of striatal cholinergic neuron morphological subtypes (unipolar, bipolar, or multipolar).

Cholinergic neuron loss is a cardinal feature of Alzheimer's disease, a progressive brain disorder affecting memory, learning, attention and other cognitive processes.

Not exact matches

They narrowed the circuit down even further by determining which neurons in these brain regions both expressed dati and were cholinergic.

Vinogradova OS, Brazhnik ES, Kitchigina VF, Stafekhina VS. Modulation of the reaction of hippocampal neurons to sensory stimuli by cholinergic substances.

Maturation of postsynaptic nicotinic structures on autonomic neurons requires innervation but not cholinergic transmission.

His lab is currently investigating the organization and function of a vastly underexplored but potentially highly important neural pathway from the cholinergic MT to DA neurons, and seeking potential causes, as well as molecular and cellular targets for treating schizophrenia.

NGF maintains and regulates the cholinergic phenotype of basal forebrain neurons [110, 111].

In the nematode worm, C. elegans, cholinergic inputs to DD motor neurons are relocated to new positions during early larval development.

YanGang Sun, Juan Pita - Almenar, Chia - Shan Wu, John J Renger, Victor N. Uebele, Hui - Chen Lu, Michael Beierlein (2013) «Biphasic cholinergic synaptic transmission controls action potential activity in thalamic reticular nucleus neurons», Journal of Neuroscience 33: 2048 - 59.

We recently identified two MB output neuron (MBON) classes whose axons convey sleep control signals from the MB to converge in the same downstream target region: a cholinergic sleep - promoting MBON class and a glutamatergic wake - promoting MBON class.

Hypocretin Neurons upregulate the production of molecules down several other pathways, too: these include noradrenergic, histaminergic, cholinergic, dopamine, and serotonergic.