We recently identified two MB output neuron (MBON) classes whose axons convey sleep control signals from the MB to converge in the same downstream target region:
a cholinergic sleep - promoting MBON class and a glutamatergic wake - promoting MBON class.
Specifically, we found that sleep - promoting KCs increase sleep by preferentially activating
cholinergic sleep - promoting MBONs, while wake - promoting KCs decrease sleep by preferentially activating glutamatergic wake - promoting MBONs.
Not exact matches
The team then investigated whether the chemical might be inducing
sleep by acting on the
cholinergic neurons in the basal forebrain.
C. Van Dort et al. «Optogenetic activation of
cholinergic neurons in the PPT or LDT induces REM
sleep.»
Our studies reveal the existence of two segregated excitatory synaptic microcircuits that propagate homeostatic
sleep information from different populations of intrinsic MB «Kenyon cells» (KCs) to specific
sleep - regulating MBONs:
sleep - promoting KCs increase
sleep by preferentially activating the
cholinergic MBONs, while wake - promoting KCs decrease
sleep by preferentially activating the glutamatergic MBONs.
I've always been overly stressed and have had
sleep problems since I was a kid, so my guess is that the chronic hyperglycemia has disrupted my parasympathetic nervous system, causing an decrease in the
cholinergic anti-inflammatory pathway (joint problems) and also the nervousness / sleeplessness / anxiety problems.