Not exact matches
The results showed that, when applied, a long - term inhibition of Rho - kinase signaling increased the expressions of
chondrocyte - specific genes and
differentiation markers in human chondrosarcoma 2/8 cells.
By contrast, the R206H ACVR1 mutant only slightly enhances the expression of initial and early chondrogenesis
markers (collagen type II and aggrecan), consistent with a milder stimulatory effect of the FOP ACVR1 mutation on
chondrocyte differentiation.
A short - term inhibition of Rho - kinase failed to induce extracellular matrix production in fibroblasts or in HCS - 2 / 8 cells, while its long - term exposure increased the expressions of
chondrocyte - specific genes and
differentiation markers, and also promoted the synthesis of sulfated glycosaminoglycans by chondrocytic cells.