Sentences with phrase «chondrocytes by»

p38 kinase regulates nitric oxide - induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B - dependent transcription and stabilization by serine 15 phosphorylation.

Effects of microRNA - 146a on the proliferation and apoptosis of human osteoarthritis chondrocytes by targeting TRAF6 through the NF -?

Not exact matches

To create a new bioink, Gatenholm's team mixed polysaccharides from brown algae and tiny cellulose fibrils from wood or made by bacteria, as well as human chondrocytes, which are cells that build up cartilage.

One exciting potential for Permacol is that it can be seeded with the patient's own cells, so that in the future it may be possible to repair cartilage or bone by seeding with chondrocytes or osteocytes.

«Our paper is a blueprint of how the cartilage - producing cell, called a chondrocyte, is made and maintained by Sox9,» said He, a postdoctoral research associate in the lab of Andy McMahon, director of the Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC.

The Rho - kinase inhibition stimuli under low oxygen conditions (of 5 percent oxygen atmosphere), which is a condition corresponding to conditions in the body's cartilage, produced a more effective increase in chondrocyte - specific gene expression and synthesis of extracellular matrix components by HCS - 2 / 8 cells.

The findings suggest that reductions in the number of cartilage - producing cells, and greater risk for osteoarthritis, may be driven not just by lower adenosine levels but also by lower levels of the protein on the surface of chondrocytes designed to receive and pass on adenosine's signal.

By contrast, the R206H ACVR1 mutant only slightly enhances the expression of initial and early chondrogenesis markers (collagen type II and aggrecan), consistent with a milder stimulatory effect of the FOP ACVR1 mutation on chondrocyte differentiation.

A short - term inhibition of Rho - kinase failed to induce extracellular matrix production in fibroblasts or in HCS - 2 / 8 cells, while its long - term exposure increased the expressions of chondrocyte - specific genes and differentiation markers, and also promoted the synthesis of sulfated glycosaminoglycans by chondrocytic cells.

Interestingly, Rho kinase inhibition under hypoxic conditions produced a more effective increase in chondrocyte - specific gene expression and synthesis of extracellular matrix components by HCS - 2 / 8 cells.

Effect of preculture and loading on expression of matrix molecules, matrix metalloproteinases, and cytokines by expanded osteoarthritic chondrocytes.

The cartilaginous matrix is composed of collagen and proteoglycans, and is generated by cartilage cells that are called chondrocytes.

Specifically, MSCs are usually confirmed to be MSCs by showing that they can differentiate into three different, standard mesenchymal cell types: osteocytes (bone), chondrocytes (cartilage), and adipocytes (fat).

Research Paper MicroRNA - 193b - 3p regulates chondrogenesis and chondrocyte metabolism by targeting HDAC3 Fangang Meng, Zhiwen Li, Zhiqi Zhang, Zibo Yang, Yan Kang, Xiaoyi Zhao, Dianbo Long, Shu Hu, Minghui Gu, Suiwen He, Peihui Wu, Zongkun Chang, Aishan He, Weiming Liao Theranostics 2018; 8 (10): 2862 - 2883.

Thus, SOX9 expression in chondrocytes involves various transcriptional modules regulated by SOX9 itself and by other factors.