Sentences with phrase «chondrocytes from»

Not exact matches

This may entail making small holes in the bone to allow new cartilage to grow (microfracture), taking cartilage from another part of the athlete's knee and transplanting it into the defect (osteochondral autograft transfer), taking cartilage cells from the knee and then having them grown in a lab for later re-implantation (autologous chondrocyte implantation), or taking cartilage from a person who has passed away and placing it in the defect (osteochondral allograft transfer).

Then, to boost the number of cells, which is another hurdle in tissue engineering, the researchers mixed the chondrocytes with human mesenchymal stem cells from bone marrow.

Preliminary data from in vivo testing over 60 days show the combination does indeed encourage chondrocyte and cartilage production.

To create a new bioink, Gatenholm's team mixed polysaccharides from brown algae and tiny cellulose fibrils from wood or made by bacteria, as well as human chondrocytes, which are cells that build up cartilage.

«Cartilage cells (or chondrocytes) isolated and expanded from cartilage tissue have great potential as a cell - based therapy for patients with, for example, traumatic cartilage defects,» says Juha Piltti, doctoral student at the Department of Integrative Medical Biology.

Researchers at the Feinstein Institute know how to make cartilage from a mixture of cells called chondrocytes, nutrients to feed them, and collagen, which holds it all together.

Furthermore, organ cultured cartilage from ACH mice treated with statin resulted in increased expression of the aforementioned three genes and also in Runx2 and Col10a1, which indicated that statin stimulated both the differentiation and maturation of ACH mouse chondrocytes.

Additional tests in tissue samples from osteoarthritic patients who had joint replacements at NYU Langone found similarly increased levels of adenosine A2A receptors on chondrocytes.

Cronstein and his team also found that levels of adenosine A2A receptors went up on rat chondrocytes when osteoarthritis was present, in what the researchers say was a «failed attempt» to compensate for the loss of adenosine from the energy - processing (metabolic) changes underlying the inflammation.

According to the research team, the relevance of their findings to human disease was validated using chondrocytes isolated from arthritic patients.

These cells included chondrocytes (cartilage cells) that were made from mesenchymal stem cells that had been taken from her bone marrow; turning these MSCs into chondrocytes only took researchers three days.

In addition to iPS cells derived from progeria - patients, the researchers successfully applied their method to adult mesenchymal stem cells, which can differentiate into a variety of cell types, including adipocytes, osteoblasts, chondrocytes, cardiomyocytes, and, as described lately, beta - pancreatic islets cells.

In an attempt to bring patient - specific induced pluripotent stem cell (iPSCs) technology closer to the clinic, researchers have created iPSCs from patient - derived chondrocytes, using an non-integrative reprogramming method, and used these to then create large numbers of cartilage producing cells.

We investigated genes and pathways that mark OA progression in isolated primary chondrocytes taken from paired intact versus degraded articular cartilage samples across 38 patients undergoing joint replacement surgery (discovery cohort: 12 knee OA, replication cohorts: 17 knee OA, 9 hip OA patients).

Both control iPSCs derived from BJ fibroblasts (f - iPSCs) and chondrocyte derived - iPSCs (C - iPSCs) were fully pluripotent and genomically stable (See figure), and were first differentiated in a monolayer exposing the iPSCs in a defined, three stage manner to activin A, WNT3A, FGF2, BMP4, follistatin, GDF5, and neurotrophin 4.