This week, University of California, Davis, researchers reveal the discovery of a genetic mutation across breeds that is responsible
for chondrodystrophy (the skeletal disorder leading to shorter legs and abnormal intervertebral discs) in a study published in the Proceedings of the National Academy of Sciences.
«There's a lot of literature that points to
chondrodystrophy in dogs as an exciting animal model for degenerative disc disease in people,» said Bannasch, who also holds the Maxine Adler Endowed Chair in Genetics.
In these breeds,
chondrodystrophy predisposes the discs to being prematurely converted to an abnormal type of tissue, whose consistency is unsuitable for the discs» function.
The bulldog's unusual appearance arises from a condition known
as chondrodystrophy, a form of dwarfism, where cartilage and connective tissue develop abnormally.
Researchers from the University of California, Davis, believe they've discovered a genetic mutation that spans dog breeds and is responsible
for chondrodystrophy.
In chondodystrophic breeds such as Dachshunds, Bulldogs and Bassett Hounds,
chondrodystrophy is seen as characteristic angular limb deformities and abnormally short legs otherwise known as hereditary dwarfism.
Problems relating to
chondrodystrophy are impossible to avoid entirely when picking a French Bulldog puppy, as all Frenchies have this type of dwarfism.
Zoological Society of San Diego scientists will study the genetic basis for
chondrodystrophy, a lethal form of dwarfism in California condors, to help guide decisions about birds released into the wild or paired in captivity.