Sentences with phrase «chondrogenesis assays»

However, chondrogenesis assays in chick micromass cultures showed that enhanced signaling by the mutant R206H ACVR1 can be partially inhibited by the BMP antagonist Noggin, suggesting that in addition to BMP - independent activity by the R206H ACVR1 receptor, this mutant receptor is also responsive to BMP, consistent with previous BMP signaling pathway studies that used cells derived from FOP patients (48 — 50).

In vitro chondrogenesis assays demonstrated that the R206H ACVR1 mutation can stimulate progenitor cells to differentiate to cartilage in concert with the appropriate cell environment and differentiation factors and that this mutant receptor activates BMP signaling constitutively without BMP stimulation.