Not exact matches
By contrast, the R206H ACVR1 mutant only slightly enhances the expression of initial and early
chondrogenesis markers (collagen type II and aggrecan), consistent with a milder stimulatory effect of the FOP ACVR1 mutation on chondrocyte differentiation.
However,
chondrogenesis assays in chick micromass cultures showed that enhanced signaling
by the mutant R206H ACVR1 can be partially inhibited
by the BMP antagonist Noggin, suggesting that in addition to BMP - independent activity
by the R206H ACVR1 receptor, this mutant receptor is also responsive to BMP, consistent with previous BMP signaling pathway studies that used cells derived from FOP patients (48 — 50).
The condensation phase of mesenchymal prechondrogenic cells is the first event in
chondrogenesis, characterized
by the expression of collagen type II (44).
Research Paper MicroRNA - 193b - 3p regulates
chondrogenesis and chondrocyte metabolism
by targeting HDAC3 Fangang Meng, Zhiwen Li, Zhiqi Zhang, Zibo Yang, Yan Kang, Xiaoyi Zhao, Dianbo Long, Shu Hu, Minghui Gu, Suiwen He, Peihui Wu, Zongkun Chang, Aishan He, Weiming Liao Theranostics 2018; 8 (10): 2862 - 2883.