Sentences with phrase «choroidal angiogenesis»
Our objective is to determine whether this mutation is involved in AMD by (1) understanding the functional consequences of this genomic variation on expression of COL8A1 and / or its neighbor genes, and (2) investigating photoreceptors and RPE cell survival, retinal and choroidal angiogenesis, structure integrity of the choroid / Bruch's membrane, and the quality of the vision, in organisms with the COL8A1 mutation.
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Specifically, the team hypothesizes that microRNA miR - 24 is a key regulator of actin cytoskeleton dynamics (i.e. the inner structural support of a cell); therefore, it plays a critical role in regulating multiple disease processes, including the angiogenesis (blood vessel growth), inflammation, and fibrosis (thickening and scarring of tissue) associated with choroidal neovascularization (CNV) in wet AMD.