Sentences with phrase «chromatin architecture in»
Surprisingly, the researchers found a similar bimodal 3 - dimensional chromatin architecture in the Hoxd gene region in zebrafish embryos.
https://www.sciencedaily.com/ Not exact matches
Additionally, we found that DNA loss events tended to be smaller than DNA gain events suggesting that they were able to accumulate in gene - rich open chromatin regions due to their reduced capacity to interrupt gene regulatory architecture.
The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.
The lab investigates consequences of epigenetic alterations in neuronal cancers and neurodegenerative diseases using a combination of biochemistry, cell and molecular biology with genome wide approaches to gain mechanistic insight into how chromatin architecture is modified in disease.
The Kind group uses these techniques to study the role of genome architecture and chromatin context in temporal and spatial control of gene expression in development and disease.