Sentences with phrase «chromatin epigenetic marks»
The pluripotent population is characterized by a high degree of plasticity in chromatin structure [3], and lineage specific transcription factors show bivalent chromatin epigenetic marks characteristic of both suppression and inactivation [4].
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The Max Planck researchers found that H3K27me3 modifications labeling chromatin DNA in the mother's egg cells were still present in the embryo after fertilization, even though other epigenetic marks are erased.
«We didn't set out to study the relationship between the epigenetic chromatin marks and gene expression during development, but rather to analyze the function of these marks in DNA processing.
Dr. Loftus» current research integrates the identification of these types of epigenetic modifications that mark the melanocyte regulatory genomic landscape with regulatory protein and transcription factor chromatin - binding domains, thus defining groups of non-coding DNA sequences utilized in the control of melanocyte gene expression.
The overall goal of the core is to provide support to investigators interested in characterizing the interactions of post-translational modifications of histones (epigenetic marks that define a chromatin state or Epigenome) or transcription factors at specific genomic loci or genome - wide (Cistrome).
Lausanne, Switzerland About Blog Epigenomics and Epigenetics queries the developmental origins of health and disease by cataloguing the sets of physical markings on chromatin that collaborate to stably alter gene expression.