Sentences with phrase «chromatin regulation of gene»

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Analysis of the tumor genes affected by the two drugs revealed that cabazitaxel had a greater effect on cellular division and regulation of chromatin — a spool for DNA that helps control which genes are in use and when — whereas docetaxel has a greater impact on DNA transcription and repair.

Weaving together perspectives from the fields of gene regulation and chromatin, Turner offers a concise discussion of the relations between the packing and organization of DNA within the cell nucleus and the regulation and expression of genes.

The modern study of gene regulation started in the 1950s, but researchers only started to unravel the complex array of histone modifications that fine - tune chromatin control of gene expression 20 years ago.

Indeed, to get the full picture of gene regulation we need to look at the three - dimensional organisation of the chromatin that also coordinates gene activity.»

We had suspected that the Mycoplasma genome might have a similar overall organisation to other bacteria, but we were completely surprised to find that it was also organised into domains, which can be considered as regulatory units of chromatin organisation and that we had identified a previously unknown layer of gene regulation.

Chromatin structure contributes to the epigenetic regulation of gene expression, DNA replication or DNA repair.

The initial work was mainly focused on the study of the regulation of muscle chromatin and gene expression by motor innervation.

He joined the Dimitris Thanos lab «at the perfect time,» when a growing appreciation of the importance of chromatin in gene regulation presented many opportunities for the ambitious and eager young scientist.

Expression changes of these genes suggest a possible form of gene regulation through the alteration of the chromatin structure.

Research by Sharon Dent and colleagues revealed for the first time that histone modifications - instead of being an end - point for transcriptional regulation - can actually relay information to non-histone proteins, and that the role of chromatin in these events is not limited to DNA - templated events like gene activation.

The non-catalytic interactions were enriched for gene regulation with chromatin modification being one of the most striking.

Sessions will cover recent findings in RNA polymerase II regulation, including the contributions of noncoding RNAs, chromatin structure and post-translational modifications, and other factors that regulate gene expression.

The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.

Examples of these include cell proliferation, intracellular targeting, cell polarity, membrane traffic, cell migration, stem cell biology, chromatin regulation and function, differentiation, morphogenesis and biomechanics, and regeneration and cellular homeostasis, as well as developmental roles of genes, cellular structural dynamics, and signaling pathways.

We found that genes within islands of differentiation were enriched for several functional classes (Table S4), and most terms were related to transcription and epigenetic pathways (e.g. chromatin organization and modification, regulation of transcription and translation, DNA binding).

These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription.

The structure of chromatin determines the accessibility of various proteins to genes and therefore plays an important role in genomic regulation.

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

More recently, it has been suggested that the contrasting attributes of gene compactness, GC content and the length of the intronic and intergenic sequences in Hkg and Tsg might be involved in chromatin mediated regulation for maintaining distinct expression patterns in the gene sets [29].