Sentences with phrase «chromatin regulation of gene expression»
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Weaving together perspectives from the fields of gene regulation and chromatin, Turner offers a concise discussion of the relations between the packing and organization of DNA within the cell nucleus and the regulation and expression of genes.
http://science.sciencemag.org/
The modern study of gene regulation started in the 1950s, but researchers only started to unravel the complex array of histone modifications that fine - tune chromatin control of gene expression 20 years ago.
Chromatin structure contributes to the epigenetic regulation of gene expression, DNA replication or DNA repair.
The initial work was mainly focused on the study of the regulation of muscle chromatin and gene expression by motor innervation.
Expression changes of these genes suggest a possible form of gene regulation through the alteration of the chromatin structure.
Sessions will cover recent findings in RNA polymerase II regulation, including the contributions of noncoding RNAs, chromatin structure and post-translational modifications, and other factors that regulate gene expression.
The Sarma laboratory is interested in the mechanisms of epigenetic gene regulation, or how the dynamic modifications of the architecture of chromatin, the complex of DNA and proteins within the nucleus of our cells, impacts gene expression and cellular function.
These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription.
More recently, it has been suggested that the contrasting attributes of gene compactness, GC content and the length of the intronic and intergenic sequences in Hkg and Tsg might be involved in chromatin mediated regulation for maintaining distinct expression patterns in the gene sets [29].