Sentences with phrase «chromatin states in»

According to this model, differentiation is a gradual transition from an open and permissive chromatin state in multipotent stem cells to a compacted cell - type specific chromatin state in differentiated cells.

Not exact matches

He said that the loss of Set2 keeps the chromatin in a more open state — not as compact as normal.

An international team headed by Kikuë Tachibana - Konwalski from IMBA in collaboration with researchers from the Massachusetts Institute of Technology (MIT) in Boston and the Lomonosov Moscow State University (MSU) aimed to uncover how chromatin structure is reorganized during the mammalian oocyte - to - zygote transition.

Having established some understanding of the open chromatin landscape in healthy mice, the researchers now hope to figure out how these relationships change with disease states.

In the scientific article «Histone mutations separate R loops from genome instability induction» published in Molecular Cell, the researchers state that RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNIn the scientific article «Histone mutations separate R loops from genome instability induction» published in Molecular Cell, the researchers state that RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNin Molecular Cell, the researchers state that RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNin the DNA.

It has also been suggested that methylation is not the initial event in triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).

Chromatin states sometimes predicted differences in RNA expression that weren't captured by DNA methylation or accessibility measurements.

The permissiveness, in turn, seems to be defined by a triad of chromatin modifications, which are depicted here, so those sides marked by a trivalent state, Ascl1 combined.

So what we think is that probably in many cells in this section, all cells, the chromatin is encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.

While if the chromatin is found in another state, no binding occurs and, thus, also no chromatin opening, and ultimately no reprogramming.

Luke Buchanan (Stewart, TUD)-- «Mechanisms of chromatin state definition in Schizosaccharomyces pombe» (2008)

Opening the way to accurately profile the chromatin states of in vivo stem cells, lineage progenitors and other scarce cell populations.

When histones are bound to the DNA, the chromatin is in a condensed state (called heterochromatin) and the genes are not expressed because they can not be accessed by the gene transcription machinery.

Chd1 may function in ESCs to maintain chromatin in an open (euchromatin) state and potentially promote pluripotency in this way.

The business end of ALC1 is a motor domain that, just like in other chromatin remodeling enzymes, can hydrolyze ATP as fuel to move the enzyme along DNA and to change the packaging state of chromatin.

Histone modifications, particularly methylation and acetylation, are generally involved in chromatin state regulation.

Overall, this study highlights the close links between transcription factor - driven genome topology dynamics, chromatin state, and gene expression and highlights a critical role for genome topology in enforcing transcriptional programs and cell fate.

Our results reveal the regulatory mechanisms that interplay to drive transcription factor occupancy, chromatin state, and gene expression in complex mammalian cell states.

These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription.

In the past few years, ChIP - Seq has become a very useful technique to understand the chromatin states that regulate the transcription output.

The overall goal of this core is to facilitate researchers» efforts to understand Epigenetic mechanisms that alter the chromatin state that regulate the transcription output in normal vs. disease conditions.

The overall goal of the core is to provide support to investigators interested in characterizing the interactions of post-translational modifications of histones (epigenetic marks that define a chromatin state or Epigenome) or transcription factors at specific genomic loci or genome - wide (Cistrome).

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

Hypotetical model on the role chromatin remodelling in auxin and stress induced somatic embryogenesis influenced by the genotype and the developmental state of the explant.

Looking more closely at the passage above and comparing it to the content of the National Science Education Standards (NSES)(National Research Council, 1996) shows that a single paragraph from the most commonly used high school biology textbook in the United States includes at least six scientific terms (eukaryotic, chromosome, prokaryote, chromatin, histone, and nucleosome) that are, unlike DNA and protein, not included in the NSES.