Sentences with phrase «chromatin states of»

Opening the way to accurately profile the chromatin states of in vivo stem cells, lineage progenitors and other scarce cell populations.

By studying the chromatin state of zygotes, we aim to gain insights into this mechanism, which could also have applications for regenerative medicine,» says Tachibana - Konwalski, underlining her excitement for the potential applications for her favourite research topic.

Not exact matches

«This means that these histone modifications might be a way through which the metabolic state of the cell is linked to chromatin architecture.»

He said that the loss of Set2 keeps the chromatin in a more open state — not as compact as normal.

Understanding this specialized chromatin «ground state» has the potential to provide insights into the yet mysterious process of epigenetic reprogramming to totipotency, the ability to give rise to all cell types.

An international team headed by Kikuë Tachibana - Konwalski from IMBA in collaboration with researchers from the Massachusetts Institute of Technology (MIT) in Boston and the Lomonosov Moscow State University (MSU) aimed to uncover how chromatin structure is reorganized during the mammalian oocyte - to - zygote transition.

Having established some understanding of the open chromatin landscape in healthy mice, the researchers now hope to figure out how these relationships change with disease states.

In the scientific article «Histone mutations separate R loops from genome instability induction» published in Molecular Cell, the researchers state that RNA joins with DNA by chance or because of a disease, the structure of the chromatin, the protein envelope of the chromosomes is altered, causing breaks in the DNA.

It has also been suggested that methylation is not the initial event in triggering gene silencing in cancer; rather, the methylation of the promoter CpG islands is a consequence of prior gene inactivation, and it is a mechanism for locking the chromatin in a repressed state (5, 13, 37).

The authors first generated a common set of chromatin states across 127 epigenomes (111 of their own, and 16 more borrowed from ENCODE), all of which had been profiled for five core histone marks.

The permissiveness, in turn, seems to be defined by a triad of chromatin modifications, which are depicted here, so those sides marked by a trivalent state, Ascl1 combined.

Next, the authors turned to their other epigenomic profiling datasets — DNA accessibility (DNAse - Seq), methlation (bisulfite sequencing), and RNA transcription (RNA - Seq) to examine and compare the properties of these chromatin states.

So what we think is that probably in many cells in this section, all cells, the chromatin is encountered in a specific state, and in order to render the cell is permissive to reprogramming, you have to overcome these certain epigenetic modifications that block, for example, the binding of Ascl1 to its target chains, or the binding of other transcription factors to its target chains, then this way interfere with the possibility of reprogramming.

Luke Buchanan (Stewart, TUD)-- «Mechanisms of chromatin state definition in Schizosaccharomyces pombe» (2008)

We have studied the mechanism of RSC - induced chromatin remodeling by using high resolution microscopy and state of the art biochemistry techniques.

The business end of ALC1 is a motor domain that, just like in other chromatin remodeling enzymes, can hydrolyze ATP as fuel to move the enzyme along DNA and to change the packaging state of chromatin.

ATP - dependent chromatin remodelers are enzymes specialized on altering the structure and packaging state of chromatin.

However, researchers from the laboratories of Ralph Stadhouders, Marc A. Marti - Renom, and Thomas Graf have now applied a highly efficient and synchronous reprogramming system [2, 3] to study how genome topology, chromatin states, and gene expression dynamically change during reprogramming [4].

Cell - fate conversion requires the dynamic reorganization of chromatin states and alterations to the active and repressed sub-nuclear compartments

These services are aimed to deliver high quality sequencing - ready libraries to map chromatin states (histone modifications), or profile binding of epigenetic modifiers (transcription co-regulators) or DNA binding proteins (transcription factors) on a genomic scale.

Together, these data define METTL3 as a regulator of a chromatin - based pathway that is necessary for maintenance of the leukaemic state and identify this enzyme as a potential therapeutic target for acute myeloid leukaemia.

These findings provide new insights into how chromatin regulation modulates stochastic gene expression and transcriptional bursting, with implications for regulation of pluripotency and development.Polycomb repressive complexes modify histones but it is unclear how changes in chromatin states alter kinetics of transcription.

The overall goal of this core is to facilitate researchers» efforts to understand Epigenetic mechanisms that alter the chromatin state that regulate the transcription output in normal vs. disease conditions.

These proteins are what recognize the methylation state of a given gene and recruit repressive chromatin.

The overall goal of the core is to provide support to investigators interested in characterizing the interactions of post-translational modifications of histones (epigenetic marks that define a chromatin state or Epigenome) or transcription factors at specific genomic loci or genome - wide (Cistrome).

We have found that blastocysts produced by suboptimal IVC exhibit transcriptional repression of some genes (Sox2, Hdac1, Kap1, Dnmt1, and Dnmt3a) that are modifiers of epigenetic gene silencing through the regulation of the transcription of specific genes, which involves changes in the chromatin state.

Hypotetical model on the role chromatin remodelling in auxin and stress induced somatic embryogenesis influenced by the genotype and the developmental state of the explant.

Looking more closely at the passage above and comparing it to the content of the National Science Education Standards (NSES)(National Research Council, 1996) shows that a single paragraph from the most commonly used high school biology textbook in the United States includes at least six scientific terms (eukaryotic, chromosome, prokaryote, chromatin, histone, and nucleosome) that are, unlike DNA and protein, not included in the NSES.