Sentences with phrase «chromosome organization»
The Noma laboratory has studied 3D chromosome organizations in the fission yeast model organism and the more complex human system.
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Next, Dekker and the team, led by Leonid Mirny, PhD, associate professor at the Massachusetts Institute of Technology, developed sophisticated computer simulations using polymer models of the DNA molecule for the two competing theories for mitotic chromosome organization.
Recent studies have started to map the gene - wide chromatin interactions in the interphase nucleus, revealing some principles of chromosome organization into territories, and dramatic changes of chromatin organization and interactions during differentiation and lineage specification.
We found that the interaction between two classic factors, condensin and TBP, plays a pivotal role in 3D chromosome organization, and ensures that a critical set of genes, the actively transcribed housekeeping genes, are accurately segregated during mitosis (Figure B and C).
Julia's lab studies chromosome organization and the maintenance of genome integrity, with mechanisms of telomere function as a springboard.
«We now have a model that incorporates this seemingly contradictory data and points to a single and simple process for condensed chromosome organization across all cell types.
«Chromosome organization emerges from 1 - D patterns: Scientists use epigenetic marks to predict how DNA folds.»
Prior to Joining IDRI, Matthew worked at the Institut de Biologie Integrative de la Cellule, France with Dr. Frederic Boccard applying super resolution microscopy to study the temporal and spatial localization of proteins involved in bacterial chromosome organization.
In an article that appears in the online edition of Science, UMMS Professor Job Dekker, PhD, and colleagues show new evidence for a general principal of condensed, mitotic chromosome organization and structure that is highly adaptable and common to all cells.
UMMS Professor Job Dekker, PhD, and colleagues show new evidence for a general principal of condensed, mitotic chromosome organization and structure that is highly adaptable and common to all cells.
William Sullivan (UCSC), collaborator of this work, adds: «Like a car with its engine out of tune, over many cell divisions this is likely to result in severe disruptions in chromosome organization.»
These studies are typically based on chromosome capture techniques that require many nuclei and provide a static picture of the chromosome organization in the nucleus.