Different levels of
chromosome segregation errors have different consequences for tissues and organisms, ranging from oncogenic to tumor suppressive to lethal.
Combining this with various cancer models will reveal when and where certain levels of
chromosome segregation errors impact organismal health and tumor development.
Not exact matches
The altered movement of the microtubules apparently contributes to
errors in
chromosome segregation, and so represents a new explanation for age - related infertility,» stated CRCHUM researcher and Université de Montréal professor Greg FitzHarris.
The researchers then confirmed that the number of singly paired
chromosomes — also called univalents — was higher in older mouse and even human egg cells, indicating that age - related
segregation errors could be tracked back to increased numbers of prematurely separated
chromosome pairs.
To determine the most common type of age - related
segregation errors, the researchers first used a novel high resolution imaging technique to visualize
chromosomes in live mouse egg cells throughout the whole first stage of meiosis.
They found that
chromosomes were always distributed correctly in young egg cells, but that a little less than 10 % of older cells suffered from
segregation errors.
When there is more (polyploidy) or less (haploidy), mitosis is more prone to
errors during the
segregation of the
chromosomes and this activates p53.
Partly based on his MIT Ph.D. thesis research performed in yeast, Sheltzer suspects aneuploidy causes
errors in DNA replication, as well as problems with
chromosome segregation during cell division.
We wish to understand which mutations underlie this disease and how these mutations cause
errors in
chromosome segregation.
Errors in
chromosome segregation are a major cause for birth defects and embryonic lethality in humans, and the most common genetic alteration in human tumors is aberrant
chromosome numbers, called aneuploidy.
Finally, as we and others have shown,
errors in
chromosome segregation during mitosis have dramatic secondary consequences on genome integrity, including translocations, deletions and
chromosome shattering (chromothripsis).
Aneuploidy is a manifestation of a Chromosomal Instability (CIN) phenotype: the tendency of a cell to make frequent
errors in
chromosome segregation.
Errors in
chromosome segregation can cause birth defects and embryonic lethality in humans and cause aneuploidy, the most common genetic alteration in tumors.
Among these,
errors of
chromosome segregation lead to infertility.