By blocking a specific cell signaling pathway in lab animals, researchers reversed signs
of chronic immune activation, thereby boosting T - cell recovery and viral suppression.
To test
if chronic immune activation could be responsible for the high antiviral protection and life - shortening by wAu we examined the expression of genes encoding antimicrobial peptides (AMPs).
«Although the underlying mechanism leading to this increase in AMD in persons with AIDS is not yet known, it may relate to the state
of chronic immune activation and systemic inflammation seen in these patients,» said Dr. Jabs.
The researchers conclude that they «identified adipose tissue as a crucial cofactor in both viral persistence and
chronic immune activation / inflammation during HIV infection,» and propose that «modulating adipose tissue may constitute a valuable means of limiting both viral persistence and chronic inflammation in ART - receiving HIV - infected patients.»
On the other hand,
chronic immune activation was also proven to be responsible for lifespan reduction in Drosophila melanogaster [45].
The detrimental effects of
chronic immune activation, which is the result of HIV infection, have become increasingly clear.
The researchers divided the 220 children into two categories — those with mothers who reported a history of
chronic immune activation (caused by asthma and allergies) and those with mothers who reported a diagnosis of an autoimmune condition, such as diabetes and thyroid problems.