«If part of this is related to obesity, moderate exercise and reducing body weight can reduce
chronic inflammation in the brain,» he said.
What we think may be happening here is that environmental exposures may be altering some people's immune responses, in a way that promotes
chronic inflammation in the brain.»
More recently, they've found that
chronic inflammation in the brain is linked to the onset and acceleration of Alzheimer's disease.
«For decades, researchers have seen
chronic inflammation in the brains of Alzheimer's patients, but they thought it was a consequence of the disease, not a cause of it,» Gan said.
Not exact matches
According to the University of Maryland Medical Center polyunsaturated fatty acids (PUFAs)-- also known as omega - 3 fatty acids — play a crucial role
in human
brain function, as well as normal growth and development, with research showing that they can also reduce
inflammation in addition to helping lower the risk of
chronic diseases such as heart disease, cancer, and arthritis.
Chronic inflammation, Burd says, may play a role
in keeping the hippocampus small, potentially because it inhibits proper
brain development.
They observed that amyloid beta plaques — which scientists believe play a major role
in the disease — were being cleared
in animals with
chronic brain inflammation.
Second, affected genes may disturb fundamental pathways
in the body and lead to
chronic inflammation across the
brain, immune system, and digestive system.
A particular type of macrophage known as microglia are found throughout the
brain and spinal cord —
in progressive forms of MS, they attack the CNS, causing
chronic inflammation and damage to nerve cells.
«Our approach to use a combination treatment of DHCA and Mal - gluc to simultaneously inhibit peripheral
inflammation and modulate synaptic plasticity
in the
brain works synergistically to optimize resilience against
chronic stress - induced depression - like phenotypes,» said Dr. Pasinetti.
So far, early efforts to treat the
chronic inflammation with a drug
in an animal model of traumatic
brain injury have revealed promising results.
Paz also thinks that
chronic inflammation in the thalamus may be behind the dramatic rise
in epilepsy following
brain damage.
However, as is the case with
chronic brain inflammation in the human body, when that immune response extends for a longer period of time, it reverses gains and fuels further neurological decline.
This could be useful not just against
inflammation such as seen
in arthritis and inflammatory bowel disease but also
chronic inflammation seen
in cardiovascular diseases and
in the
brain, where most biological drugs can't reach.
The result of this is a
chronic, wildfire - like
inflammation in the
brain.
One study showed a significant correlation between the death of nerve cells
in the
brain and
chronic inflammation.
He taught me a lot about evolutionary medicine and nutrition
in general, opened many doors and introduced me (directly and indirectly) to various players
in this field, such as Dr. Boyd Eaton (one of the fathers of evolutionary nutrition), Maelán Fontes from Spain (a current research colleague and close friend), Alejandro Lucia (a Professor and a top researcher
in exercise physiology from Spain, with whom I am collaborating), Ben Balzer from Australia (a physician and one of the best minds
in evolutionary medicine), Robb Wolf from the US (a biochemist and the best «biohackers I know»), Óscar Picazo and Fernando Mata from Spain (close friends who are working with me at NutriScience), David Furman from Argentina (a top immunologist and expert
in chronic inflammation working at Stanford University, with whom I am collaborating), Stephan Guyenet from the US (one of my main references
in the obesity field), Lynda Frassetto and Anthony Sebastian (both nephrologists at the University of California San Francisco and experts
in acid - base balance), Michael Crawford from the UK (a world renowned expert
in DHA and Director of the Institute of
Brain Chemistry and Human Nutrition, at the Imperial College London), Marcelo Rogero (a great researcher and Professor of Nutrigenomics at the University of Sao Paulo, Brazil), Sérgio Veloso (a cell biologist from Portugal currently working with me, who has one of the best health blogs I know), Filomena Trindade (a Portuguese physician based
in the US who is an expert
in functional medicine), Remko Kuipers and Martine Luxwolda (both physicians from the Netherlands, who conducted field research on traditional populations
in Tanzania), Gabriel de Carvalho (a pharmacist and renowned nutritionist from Brazil), Alex Vasquez (a physician from the US, who is an expert
in functional medicine and Rheumatology), Bodo Melnik (a Professor of Dermatology and expert
in Molecular Biology from Germany, with whom I have published papers on milk and mTOR signaling), Johan Frostegård from Sweden (a rheumatologist and Professor at Karolinska Institutet, who has been a pioneer on establishing the role of the immune system
in cardiovascular disease), Frits Muskiet (a biochemist and Professor of Pathophysiology from the Netherlands, who, thanks to his incredible encyclopedic knowledge and open - mind, continuously teaches me more than I could imagine and who I consider a mentor), and the Swedish researchers Staffan Lindeberg, Tommy Jönsson and Yvonne Granfeldt, who became close friends and mentors.
I tend to think that, probably most cases of depression and anxiety have some kind of
inflammation present, especially when we consider that just
chronic, turned on, sympathetic nervous system and high levels of cortisol is going to contribute to a cortisol resistance
in the
brain and increase neuroinflammation, especially
in the hypothalamus.
#nerdalert Omega 3's are a polyunsaturated fat (PUFA) that are key
in brain function, growth, development, help decrease
inflammation and may lower the risk of
chronic diseases like heart disease, cancer and arthritis.
Module 2 — GI Part 2 — The Spectrum of Gluten Related Disorders with special guest faculty, Tom O'Bryan, DC, CCN, DABCN Module 3 — An Integrativen and Functional Nutrition Approach to
Brain Related Disorders with special guest faculty, Jay Lombard, DO Module 4 — CardioMetabolic Disease,
Inflammation and Insulin Dysregulation with special guest faculty, Cynthia Geyer, MD Module 5 — An Integrative and Functional Nutrition Approach to Obesity and Weight Management with special guest faculty, Mark Pettus, MD Module 6 — Detoxification: The Role of Toxicity
in Chronic Disease with special guest faculty, Deanna Minich, PhD, FACN, CNS, IFMCP (NOTE: CEUs not offered for this module) Module 7 — An Integrative and Functional Nutrition Approach to Cancer Therapies with special guest faculty, Dr Lisa Alschuler, ND, FABNO Module 8 — Adrenal, Thyroid and Hormonal Dysfunction with special guest faculty Joel Evans, MD (NOTE: CEUs not offered for this module) Module 9 — Energy and Pain Disorders / Mitochondropathy with special guest faculty Robin Foroutan, MS, RDN, HHC
In this podcast I discuss some of the mechanisms by which
chronic stress (and rumination) affect the
brain and
brain aging, the gut and
inflammation, the immune system, and biological aging through acceleration of telomere shortening.
In chronic Lyme and associated diseases Curcumin is an essential herb that decreases pain limits and improves Herxheimer die - off reactions, boosts the immune system by lowering
inflammation cytokines, decreases
brain injury and damage, and may kill Lyme and co-infection germs.
Blood sugar dysregulation is a significant stressor
in the
brain and disrupts the Blood Brain barrier, which is designed to protect the brain from oxidative stress, infectious microbes, toxic debris and chronic inflamma
brain and disrupts the Blood
Brain barrier, which is designed to protect the brain from oxidative stress, infectious microbes, toxic debris and chronic inflamma
Brain barrier, which is designed to protect the
brain from oxidative stress, infectious microbes, toxic debris and chronic inflamma
brain from oxidative stress, infectious microbes, toxic debris and
chronic inflammation.
It is also important
in protecting the
brain and tissue cells from abnormal growths, toxicity and
chronic inflammation.
Inflammation has been discovered to play roles
in heart disease, cancer, dementia (by inflaming
brain cells) and particularly
chronic joint pain and muscle weakness.
Leaky gut triggers
chronic inflammation in the gut, body, and
brain, along with other health problems, such as food intolerances, pain, autoimmune disorders, skin issues, joint problems, and, of course, depression.
There are instances when conventional medicine is like a miracle, but for the one
in five people suffering from autoimmune disease such as Hashimoto's hypothyroidism (a disease
in which the immune system attacks and destroys tissue
in the body or
brain), and countless others suffering from undiagnosed autoimmunity,
chronic inflammation, severe pain, environmentally induced illnesses, food sensitivities,
chronic viral, bacterial, or parasitic infections,
brain chemistry imbalances, hormonal imbalances, hair loss, unexplained weight gain, and more — being told your lab tests are fine and you simply need an antidepressant can feel like a kick
in the groin.
This excess sugar
in the bloodstream is highly damaging, damaging blood vessels and the
brain and triggering the
chronic inflammation foundational to such diseases as Hashimoto's hypothyroidism.
Insulin and leptin resistance
in turn promote obesity,
inflammation, accelerated
brain degeneration, heart disease, diabetes, autoimmunity, and hormonal imbalances —
in essence, the foundation to the many
chronic diseases of western civilization.
Insulin and leptin resistance
in turn promote obesity,
inflammation, accelerated
brain degeneration, heart disease, diabetes, autoimmune diseases such as Hashimoto's hypothyroidism, and hormonal imbalances —
in essence, the foundation to the many
chronic diseases of western civilization.
This triggers
chronic inflammation in the gut, body, and
brain, along with other health problems, such as food intolerances, pain, autoimmune disorders, skin issues, joint problems, depression, and, of course,
brain fog.
Chronic stress while the
brain and central nervous system are still developing can create ongoing
inflammation and set the stage for autoimmune disease to more easily trigger later
in life.
We can't be sure exactly how mycotoxins cause
chronic inflammation, but given how toxic and carcinogenic they are,
in the kidneys, the liver, the
brain, or wherever, it's likely that your immune system treats them as a direct threat and increases its activity to destroy them.
Chronic inflammation in the body from poor diet, chronic stress, autoimmunity, and other problems can inflame the
Chronic inflammation in the body from poor diet,
chronic stress, autoimmunity, and other problems can inflame the
chronic stress, autoimmunity, and other problems can inflame the
brain.
Leaky gut is recognized as a primary factor
in causing
chronic inflammation that not only can clog your arteries, but also inflame your joints, cause skin issues, inflame your
brain with symptoms of
brain fog, depression, or memory loss, or trigger autoimmunity.
Chronic and recurrent sinusitis, headache, cognitive and attention problems, anxiety, tremors, fatigue, chronic cough, inflammation in the nose and b
Chronic and recurrent sinusitis, headache, cognitive and attention problems, anxiety, tremors, fatigue,
chronic cough, inflammation in the nose and b
chronic cough,
inflammation in the nose and
brain...
Leaky gut is recognized as a primary factor
in causing
chronic inflammation that not only can clog your arteries, but also inflame your joints, cause skin issues, inflame your
brain with symptoms of
brain fog, depression, or memory loss, or trigger autoimmunity such as Hashimoto's hypothyroidism.
Did you know that your
brain could be keeping from you love... Or that you might be broadcasting your past heartbreak everywhere you go... And if you have
chronic pain or
inflammation, you may be
in chronic survival mode?
The condition called old dog encephalitis refers to a
chronic brain inflammation that can occur
in a dog that had distemper many years prior.
that results
in fibromyalgia (a syndrome characterised by
chronic pain
in the muscles and soft tissues surrounding joints, fatigue and tenderness at specific sites
in the body), myalgic encephalomyelitis (muscle pains and
inflammation of the
brain and spinal cord),
chronic fatigue syndrome, post-traumatic stress disorder or other anxiety disorder, any mental disorder or any disease of the nervous system;
These toxic stress - induced changes
in brain structure and function mediate, at least
in part, the well - described relationship between adversity and altered life - course trajectories (see Fig 1).4, 6 A hyper - responsive or chronically activated stress response contributes to the
inflammation and changes
in immune function that are seen
in those
chronic, noncommunicable diseases often associated with childhood adversity, like
chronic obstructive pulmonary disease (COPD), cirrhosis, type II diabetes, depression, and cardiovascular disease.4, 6 Impairments
in critical SE, language, and cognitive skills contribute to the fractured social networks often associated with childhood adversity, like school failure, poverty, divorce, homelessness, violence, and limited access to healthcare.4, 19,58 — 60 Finally, behavioral allostasis, or the adoption of potentially maladaptive behaviors to deal or cope with
chronic stress, begins to explain the association between childhood adversity and unhealthy lifestyles, like alcohol, tobacco, and substance abuse, promiscuity, gambling, and obesity.4, 6,61 Taken together, these 3 general classes of altered developmental outcomes (unhealthy lifestyles, fractured social networks, and changes
in immune function) contribute to the development of noncommunicable diseases and encompass many of the morbidities associated epidemiologically with childhood adversity.4, 6