Sentences with phrase «chronic itch»
"Chronic itch" refers to a persistent and ongoing feeling of itchiness on your skin. It is not a temporary itch, like a mosquito bite, but something that lasts for a long time. Full definition
Because little is known about what causes chronic itch, he decided to explore the connection between the two and found that the answer may be in a patient's immune system.
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The new discovery may lead to more effective treatments for chronic itching that target activity in neurons involved in both pain and itch.
The discovery could point to treatments for people who suffer from chronic itch caused by disease or medication.
One in five of us will experience chronic itch at some point and current remedies provide little relief.
It is possible that some of these might prove effective for those, like me, who suffer from chronic itch.
But now, the Buck / Berkeley team has identified a new gene that may accelerate development of chronic itch therapies.
«Scientists unravel mechanisms in chronic itching.»
Further studies discovered that the BRAF protein could turn on many itch genes, and they showed similar changes of gene expression in mice with chronic itch induced by dry skin and in mice with allergic contact dermatitis, two of the skin conditions that frequently cause people to scratch incessantly.
The findings suggest that targeting proteins in the BRAF pathway may open new avenues for treating chronic itch, a condition in which few therapies are effective.
Research done by Kim's predecessors suggested a link between chronic itch, a type of itch that lasts for more than several months, and irregularities in the immune system.
Chronic itch development in sensory neurons requires BRAF signaling pathways.
The fact that it is involved in both of those types of itch raises the possibility that the TRPV4 channel also plays a role in other types of itching, including chronic itch.
In a new study, scientists from the Florida campus of The Scripps Research Institute (TSRI) describe a class of compounds with the potential to stop chronic itch without the adverse side effects normally associated with medicating the condition.
The serotonin receptor, HTR7, caught the scientists» attention because the itchiest mice expressed the most HTR7 in the neurons that innervate the skin, and because abnormal serotonin signaling has long been linked to a variety of human chronic itch disorders, including eczema.
That helps explain why chronic itching can be so excruciating.»
That's because chronic itching appears to incorporate more than just the nerve cells, or neurons, that normally transmit itch signals.
The scientists are pursuing additional studies to map the entire chain of neurons that activate scratching in response to light touch — something that has been overlooked in the field of chronic itch until now, the team says.
Overactivation of this pathway, which most likely evolved to detect the presence of disease - bearing insects on the skin, results in increased scratching akin to that seen in patients who develop chronic itch.
This month, they published a study in the journal Science that showed that mice will scratch themselves in response to seeing videos of other mice that have chronic itch problems.
If you've ever had to deal with these annoying chronic itches, you know how uncomfortable things can be behind your bra.
Yeast infections in dogs usually produces chronic itching, infected skin, ear infections, chronic paw licking, as well as and many other visible symptoms.
CYTOPOINT ® is an injectable therapeutic medication that helps relieve chronic itch for 4 to 8 weeks, so you and your dog can get back to the fun in life.
External parasites that most commonly cause chronic itching dermatitis include fleas and various types of mange.
In fact, doctors often prescribe pain medication to patients with chronic itch.
Drugs that target KORs have shown promise as therapeutic candidates because of their efficacy for treating chronic itch and relieving pain.
A battery of follow - up experiments then validated the role of HTR7 in chronic itch.
«An estimated 10 to 20 percent of the population will suffer from chronic itch at some point in their lifetime,» said Brem.
According to Hoon, identifying the neurons that act as «specialized gatekeepers» for this system may eventually lead to drugs that offer relief for people suffering from psoriasis, eczema and other difficult - to - treat forms of chronic itch.
They also tested an alopecia drug that causes chronic itch in people.
Dermatologists have long known that available treatments for chronic itch, including eczema, are simply not up to scratch.
Today we confess not only a conflict, but a long - standing bias: First, our corporate parent, Tribune Publishing, is a player in the news story that prompts us to once again scratch a chronic itch.
And so do thousands of other folks who have suffered from diabetic neuropathy, arthritis, cold sores, shingles, post-surgical pain and pruritus, a chronic itching syndrome.
«Scientists identify promising drug candidate to treat chronic itch, avoid side effects.»
Understanding the molecular basis of chronic itch is of significant clinical interest, and now there is a new target available to explore.»
«In addition to eczema, chronic itch can stem from systemic conditions including kidney failure, cirrhosis and some cancers.
This mouse was involved in the study which identified serotonin receptor HTR7 as a key mediator of chronic itch.
The dramatic decrease in itching suggests that HTR7 may represent a new drug target for chronic itch,» said Bautista, who is an associate professor in the Department of Molecular and Cell Biology and a member of the Helen Wills Neuroscience Institute at UC Berkeley.
The researchers found that in chronic itching, neurons that send itch signals also co-opt pain neurons to intensify the itch sensation.
At first, we didn't know why they were scratching, but it turns out we developed a mouse model of chronic itch.»
«These mice are helping us to understand the pathways that can be involved in transmitting itch signals and the many contributors to chronic itching.
Working in mice, the scientists have shown that chronic itching, which can occur in many medical conditions, from eczema and psoriasis to kidney failure and liver disease, is different from the fleeting urge to scratch a mosquito bite.
«But with chronic itching, many neurons can be turned into itch neurons, including those that typically transmit pain signals.
«In people, chronic itching can last for weeks, months or even years,» Chen said.
In genetically engineered mice that are prone to chronic itching, researchers identified elevated signaling (shown in red) in nerve cells involved in both itch and in pain.
Unlike scratching a mosquito bite, which usually is only a temporary sensation, chronic itch can persist much longer, according to Chen, also a professor of psychiatry and of developmental biology.
«In the future, maybe we can specifically manipulate or modify the activity of these neurons to help people with chronic itch,» Bourane adds.
Published October 29, 2015 in the journal Science, the new results lend insights into potential mechanisms of chronic itch, which is caused by a variety of conditions such as eczema, diabetic neuropathy, multiple sclerosis and certain types of cancers.
«By targeting a single channel in the periphery, it may be possible to reduce histamine - induced itching, chloroquine - induced itching and even types of chronic itching that don't respond to current therapies.»
The team found that the antibody can also relieve acute and chronic itch in mouse models, making them the first to discover the role of Nav1.7 in transmitting the itch sensation.